THE ANTIFIBROTIC POTENTIAL OF RESVERATROL IN SCHISTOSOMA MANSONI -INFECTED MICE
SOLIMAN, R., ISMAIL, O., EL-HAMSHARY, E., HOSSINI, A. (2018). THE ANTIFIBROTIC POTENTIAL OF RESVERATROL IN SCHISTOSOMA MANSONI -INFECTED MICE. EKB Journal Management System, 48(1), 1-13. doi: 10.21608/jesp.2018.77012
RASHA H. SOLIMAN; O. A. ISMAIL; EMAN M. EL-HAMSHARY; A. H. HOSSINI. "THE ANTIFIBROTIC POTENTIAL OF RESVERATROL IN SCHISTOSOMA MANSONI -INFECTED MICE". EKB Journal Management System, 48, 1, 2018, 1-13. doi: 10.21608/jesp.2018.77012
SOLIMAN, R., ISMAIL, O., EL-HAMSHARY, E., HOSSINI, A. (2018). 'THE ANTIFIBROTIC POTENTIAL OF RESVERATROL IN SCHISTOSOMA MANSONI -INFECTED MICE', EKB Journal Management System, 48(1), pp. 1-13. doi: 10.21608/jesp.2018.77012
SOLIMAN, R., ISMAIL, O., EL-HAMSHARY, E., HOSSINI, A. THE ANTIFIBROTIC POTENTIAL OF RESVERATROL IN SCHISTOSOMA MANSONI -INFECTED MICE. EKB Journal Management System, 2018; 48(1): 1-13. doi: 10.21608/jesp.2018.77012

THE ANTIFIBROTIC POTENTIAL OF RESVERATROL IN SCHISTOSOMA MANSONI -INFECTED MICE

Journal of the Egyptian Society of Parasitology
Article 1, Volume 48, Issue 1, April 2018, Page 1-13  XML PDF (976.94 K)
Document Type: Original Article
DOI: 10.21608/jesp.2018.77012
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Authors
RASHA H. SOLIMAN1, 2; O. A. ISMAIL3; EMAN M. EL-HAMSHARY3; A. H. HOSSINI3
1Department of Parasitology, Faculty of Medicine, Suez Canal University, Ismaillia, Egypt.+
2Department of Parasitology, Faculty of Medicine, Taif University, Kingdom of Saudi Arabia.
3Department of Parasitology, Faculty of Medicine, Suez Canal University, Ismaillia, Egypt.
Abstract
Schistosoma mansoni infection continues to be one of the most serious parasitosis worldwide due to its debilitating effects, mainly hepatic fibrosis. The present study explored the antifibrotic effect of resveratrol (RSV), either alone or in combination with praziquantel, on the murine model of intestinal schistosomiasis. We performed two parallel experiments exploring the preventive and the curative effect of RSV on inflammation and fibrosis. Parasitological measurements (adult worm burden, oogram), biochemical (AST, ALT, hydroxyproline), histopathological and histobiochemical studies
were performed. The results revealed that RSV has significant curative and preventive outcome on hepatic fibrosis
and this effect is augmented when coupled with praziquantel. Other parasitological and biochemical parameters were enhanced as well.
Keywords
Schistosoma mansoni; fibrosis; Resveratrol; hydroxyproline; Immunohistochemistry
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