INSULIN RESISTANCE IN CHRONIC HEPATITIS C VIRUS PATIENTS RECEIVING DIRECT ACTING ANTIVIRAL DRUGS
ALI-ELDIN, Z., SAFWAT, E., ABDEL RAHMAN, Y., ABDELAZIZ, M., GEORGE, E. (2018). INSULIN RESISTANCE IN CHRONIC HEPATITIS C VIRUS PATIENTS RECEIVING DIRECT ACTING ANTIVIRAL DRUGS. EKB Journal Management System, 48(1), 15-20. doi: 10.21608/jesp.2018.77014
ZAINAB AHMED ALI-ELDIN; ESLAM SAFWAT; YASSER OMAR ABDEL RAHMAN; MOHAMED SAID ABDELAZIZ; EMAD NABIL GEORGE. "INSULIN RESISTANCE IN CHRONIC HEPATITIS C VIRUS PATIENTS RECEIVING DIRECT ACTING ANTIVIRAL DRUGS". EKB Journal Management System, 48, 1, 2018, 15-20. doi: 10.21608/jesp.2018.77014
ALI-ELDIN, Z., SAFWAT, E., ABDEL RAHMAN, Y., ABDELAZIZ, M., GEORGE, E. (2018). 'INSULIN RESISTANCE IN CHRONIC HEPATITIS C VIRUS PATIENTS RECEIVING DIRECT ACTING ANTIVIRAL DRUGS', EKB Journal Management System, 48(1), pp. 15-20. doi: 10.21608/jesp.2018.77014
ALI-ELDIN, Z., SAFWAT, E., ABDEL RAHMAN, Y., ABDELAZIZ, M., GEORGE, E. INSULIN RESISTANCE IN CHRONIC HEPATITIS C VIRUS PATIENTS RECEIVING DIRECT ACTING ANTIVIRAL DRUGS. EKB Journal Management System, 2018; 48(1): 15-20. doi: 10.21608/jesp.2018.77014

INSULIN RESISTANCE IN CHRONIC HEPATITIS C VIRUS PATIENTS RECEIVING DIRECT ACTING ANTIVIRAL DRUGS

Journal of the Egyptian Society of Parasitology
Article 2, Volume 48, Issue 1, April 2018, Page 15-20  XML PDF (377.44 K)
Document Type: Original Article
DOI: 10.21608/jesp.2018.77014
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Authors
ZAINAB AHMED ALI-ELDIN1; ESLAM SAFWAT1; YASSER OMAR ABDEL RAHMAN1; MOHAMED SAID ABDELAZIZ2; EMAD NABIL GEORGE3
1Department of Internal Medicine, Faculty of Medicine, Ain Shams University, Cairo Postal code 11591, Egypt.
2Department of Endemic Medicine, Faculty of Medicine, Cairo University, Cairo11562, Egypt.
3Department of Internal Medicine, Damnhour Hospital, Ministery of Health and Population, Egypt.
Abstract
Association between chronic hepatitis C (CHC) infection and insulin resistance (IR) is still challenging. The study assessed the impact of using direct acting antivirals (DAAs) on IR and the effect of IR on the treatment response. A total of 101 Egyptian patients with CHC who were eligible to Sofosbuvir based treatment were prospectively involved. All the patients were subjected to baseline liver function test, fasting and post prandial blood glucose, fasting insulin, quantitative HCV PCR and abdominal ultrasound. All the patients received sofosbuvir and daclatasvir with or without ribavirin for 12 weeks. HOMA-IR evaluated IR, both at baseline and at the end of treatment. The results showed that patients' mean age was 48.59±10.56 years; with female dominance (58.4%). An overall sustained response (SVR) was successfully achieved in 96 patients (95.04%). Baseline IR (defined as HOMA-IR >2) was identified in 64 patients (63.4%) with a median value
of 3.07. Patients with positive sustained virologic response (SVR) had lower median values of HOMA-IR than those with negative SVR; both at baseline and the end of treatment (p=0.004, p=0.04; respectively). By the end of treatment, ALT, AST, and FBG showed a significant decrease (p=0.0001). Fasting insulin and HOMA-IR showed a slight improvement (p>0.05).
Keywords
Insulin Resistance; HOMA-IR; Chronic hepatitis C; direct acting antivirals drugs
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