SERUM GLIAL FIBRILLARY ACIDIC PROTEIN AS BIOMARKER IN NEONATES WITH HYPOXIC ISCHEMIC ENCEPHALOPATHY | ||||
| Al-Azhar Journal of Pediatrics | ||||
| Article 10, Volume 21, Issue 2, June 2018, Page 2173-2184 PDF (220.4 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/azjp.2018.77259 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| Ibrahim Soliman Ibrahim; Ahmed Mohamed Ismail; Ahmed Helal Elsaid; Kamel Soliman Hamad | ||||
| Abstract | ||||
| Introduction: Hypoxic ischemic encephalopathy (HIE) is a potentially devastating condition accounts for 25% of all neonatal deaths , 40% will be affected by blindness, deafness, autism,, epilepsy, or other long-term complications( Felipe et al., 2013). Aim of work: Assessment of the level of serum glial fibrillary acidic protein (GFAP) in neonate with hypoxic ischemic encephalopathy to early identify neonates with poor prognosis. Patients and Methods: This study is a case-control study was carried out on 50 neonates babies, they were selected from (NICU) of Bab Elsharia hospital in Cairo during the period from October 2016 to March 2018. Results: In our study we found that there was statistically significant correlation between GFAP at 24 hours age and this demonstrate a concentration-dependent relationship between serum GFAP at birth and the severity of encephalopathy (Chalak et al. (2014). Conclusion: Serial increase in level GFAP from birth in HIE neonates and the severity of the hypoxic-ischemic injury can be stratified at birth and postnatal because elevated GFAP in serum correlated with severity of HIE. Recommendations: Measurement of serum GFAP in HIE within 24 hours postnatal but with large sample to early identify neonates with poor prognosis. | ||||
| Keywords | ||||
| Glial fibrilary acidic protein; hypoxic ischemic encephalopathy | ||||
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