Badr, S., Ragab, H. (2018). The Effectiveness of a Nano-Hydroxyapatite Paste and a Tri-Calcium Phosphate Fluoride Varnish in White Spot Lesions Remineralization (Randomized Clinical Trial). EKB Journal Management System, 64(Issue 3 - July (Fixed Prosthodontics, Dental Materials, Conservative Dentistry & Endodontics)), 2757-2765. doi: 10.21608/edj.2018.77273
Sherine Badr; Hala Ragab. "The Effectiveness of a Nano-Hydroxyapatite Paste and a Tri-Calcium Phosphate Fluoride Varnish in White Spot Lesions Remineralization (Randomized Clinical Trial)". EKB Journal Management System, 64, Issue 3 - July (Fixed Prosthodontics, Dental Materials, Conservative Dentistry & Endodontics), 2018, 2757-2765. doi: 10.21608/edj.2018.77273
Badr, S., Ragab, H. (2018). 'The Effectiveness of a Nano-Hydroxyapatite Paste and a Tri-Calcium Phosphate Fluoride Varnish in White Spot Lesions Remineralization (Randomized Clinical Trial)', EKB Journal Management System, 64(Issue 3 - July (Fixed Prosthodontics, Dental Materials, Conservative Dentistry & Endodontics)), pp. 2757-2765. doi: 10.21608/edj.2018.77273
Badr, S., Ragab, H. The Effectiveness of a Nano-Hydroxyapatite Paste and a Tri-Calcium Phosphate Fluoride Varnish in White Spot Lesions Remineralization (Randomized Clinical Trial). EKB Journal Management System, 2018; 64(Issue 3 - July (Fixed Prosthodontics, Dental Materials, Conservative Dentistry & Endodontics)): 2757-2765. doi: 10.21608/edj.2018.77273
The Effectiveness of a Nano-Hydroxyapatite Paste and a Tri-Calcium Phosphate Fluoride Varnish in White Spot Lesions Remineralization (Randomized Clinical Trial)
1Associate professor of Pediatric Dentistry, Faculty of Dentistry, Beirut Arab University, Beirut, Lebanon, Faculty of Oral and Dental Medicine, Cairo University, Giza, Egypt (BDS, MSc, PhD, DHPE)
2Associate professor of Operative and Esthetic Dentistry, Faculty of Dentistry, Beirut Arab University, Lebanon (BDS, MSc, PhD, Operative and Esthetics, Cairo University, Egypt)
Abstract
Objective: To evaluate and compare clinically the effectiveness of a nano-hydroxyapatite (n-HAP) paste (Sesensibilize™ Nano-P, FGM) and a tri-calcium phosphate fluoride (TCP-F) varnish (Clinpro™ White Varnish, 3M ESPE) in remineralization of white spot lesions (WSLs) on young permanent teeth. Methods: 20 patients having at least one pair of teeth with WSL were randomly selected to this study according to specific criteria. Each patient received two treatments of WSL; one treatment using n-HAP paste on one side of the arch (n-HAP group) and a second one using TCP-F varnish on the contralateral or opposing side of the arch (TCP-F group). A total of 80-teeth with WSLs were included in this randomized clinical trial. The reminaralizing agents were applied over the tooth surface with a WSL as per manufacturer recommendations. Four application sessions were completed during the first month on a weekly basis. DIAGNODENT PEN (DD) (Kavo Dental –Germany) was used to assess the degree of remineralization. DD readings were recorded at baseline, after one, three and six-months of the reminaralizing agents’ application. All patients attended the treatment sessions and remained throughout the follow-up periods. Results: There was a statistically significant difference between the WSLs mean DD readings over time for both groups (Friedman, P<0.001). The mean DD reading was 22.05 (±3.250) in n-HAP group and 21.33 (±3.467) in TCP-F group at the baseline, decreased to 10.80 (±1.7423) and 9.675 (±2.693) at one-month, 8.30 (±1.880) and 10.95(±2.726) at the 3-month, 7.875 (± 1.555) and 13.725 (±2.745) at the 6-month follow-up in n-HAP group and TCP-F group respectively. Upon comparing the groups, the WSLs had a similar mean DD reading at baseline (P>0.05). There was no statistically significant difference in the mean DD reading at one-month between the two groups (P=0.032). However, the mean DD readings were significantly lower in the n-HAP group at 3- and 6-months with high statistical significant level (P <0.001). Conclusion: The nano-hydroxyapatite paste (nano-P) and the tri-calcium phosphate varnish (clinpro) were effective in WSLs’ remineralization. Both treatment protocols could be advocated to promote remineralization of WSLs after orthodontic treatment. The nano-hydroxyapatite paste appears to demonstrate better stability than the tri-calcium phosphate varnish in its remineralization effect over the 6-month follow-up.