Preparation, Characterization and In vitro Toxicity Study of Antiparasitic Drugs Loaded onto Functionalized MWCNTs
Ayoob, F., Haroun, A., Nashy, E., mohamed, O., Abdel-Shafy, S., M. Rabie, A. (2020). Preparation, Characterization and In vitro Toxicity Study of Antiparasitic Drugs Loaded onto Functionalized MWCNTs. EKB Journal Management System, 63(10), 3829-3836. doi: 10.21608/ejchem.2020.23350.2386
Fathallah Ayoob; Ahmed Haroun; El-Shahat H.A. Nashy; ola A mohamed; Sobhy Abdel-Shafy; Abdel-Gawad M. Rabie. "Preparation, Characterization and In vitro Toxicity Study of Antiparasitic Drugs Loaded onto Functionalized MWCNTs". EKB Journal Management System, 63, 10, 2020, 3829-3836. doi: 10.21608/ejchem.2020.23350.2386
Ayoob, F., Haroun, A., Nashy, E., mohamed, O., Abdel-Shafy, S., M. Rabie, A. (2020). 'Preparation, Characterization and In vitro Toxicity Study of Antiparasitic Drugs Loaded onto Functionalized MWCNTs', EKB Journal Management System, 63(10), pp. 3829-3836. doi: 10.21608/ejchem.2020.23350.2386
Ayoob, F., Haroun, A., Nashy, E., mohamed, O., Abdel-Shafy, S., M. Rabie, A. Preparation, Characterization and In vitro Toxicity Study of Antiparasitic Drugs Loaded onto Functionalized MWCNTs. EKB Journal Management System, 2020; 63(10): 3829-3836. doi: 10.21608/ejchem.2020.23350.2386

Preparation, Characterization and In vitro Toxicity Study of Antiparasitic Drugs Loaded onto Functionalized MWCNTs

Egyptian Journal of Chemistry
Article 23, Volume 63, Issue 10, October 2020, Page 3829-3836  XML PDF (723.53 K)
Document Type: Original Article
DOI: 10.21608/ejchem.2020.23350.2386
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Authors
Fathallah Ayoob1; Ahmed Haroun email orcid 1; El-Shahat H.A. Nashy1; ola A mohamed1; Sobhy Abdel-Shafy1; Abdel-Gawad M. Rabie2
1National Research Center
2ain-shams univ, faculty of sci,
Abstract
This work focuses on the preparation of immobilized ivermectin (IVM) and essential oil carvacrol (Cav) as ‎models of antiparasitic drugs on functionalized multi-walled carbon nanotubes (MWCNTs) using sol-gel technique. ‎Fourier transform infrared spectroscopy (FTIR), transmission electron microscope (TEM) and particle size ‎distribution analysis were used to characterize the prepared materials. In addition, the in vitro cytotoxic effect was ‎investigated against normal fibroblast cell line (BHK-21) using SRB assay. Also, toxicity to Rhipicephalus ‎annulatus female ticks was also performed in vitro. The FTIR and TEM results showed that the drugs loaded on ‎the functionalized MWCNTs were successfully prepared through covalent bonding with a particle size range of ‎around 407 and 268 nm in the case of IVM and Cav, respectively. The cytotoxic activity showed that the drugs ‎loaded had low cytotoxic effects of about 4.5 and 4.4 % relative to the free IVM (8.5 %) and Cav (7.8 %), ‎respectively, at 100 μg/mL concentration. In addition, the loaded drugs displayed high ticks mortality at about 100 ‎‎% compared to the free IVM (23.3 %) and Cav (26.7 %), respectively at 250 μg/mL concentration after 72 h of ‎exposure. ‎
Keywords
Ivermectin; Carvacrol; MWCNTs; sol-gel technique, in vitro toxicity; SRB assay; Rhipicephalus annulatus ticks
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