Histological changes of tongue papillae induced by the artificial sweetener Aspartame and the protective effect of Platelet-rich plasma
Zahran, D., Mahmoud, E., Mahmoud, M. (2018). Histological changes of tongue papillae induced by the artificial sweetener Aspartame and the protective effect of Platelet-rich plasma. EKB Journal Management System, 64(Issue 2 - April (Oral Medicine, X-Ray, Oral Biology & Oral Pathology)), 1275-1282. doi: 10.21608/edj.2018.77382
Dalia H. Zahran; Elham F. Mahmoud; Mahmoud F. Mahmoud. "Histological changes of tongue papillae induced by the artificial sweetener Aspartame and the protective effect of Platelet-rich plasma". EKB Journal Management System, 64, Issue 2 - April (Oral Medicine, X-Ray, Oral Biology & Oral Pathology), 2018, 1275-1282. doi: 10.21608/edj.2018.77382
Zahran, D., Mahmoud, E., Mahmoud, M. (2018). 'Histological changes of tongue papillae induced by the artificial sweetener Aspartame and the protective effect of Platelet-rich plasma', EKB Journal Management System, 64(Issue 2 - April (Oral Medicine, X-Ray, Oral Biology & Oral Pathology)), pp. 1275-1282. doi: 10.21608/edj.2018.77382
Zahran, D., Mahmoud, E., Mahmoud, M. Histological changes of tongue papillae induced by the artificial sweetener Aspartame and the protective effect of Platelet-rich plasma. EKB Journal Management System, 2018; 64(Issue 2 - April (Oral Medicine, X-Ray, Oral Biology & Oral Pathology)): 1275-1282. doi: 10.21608/edj.2018.77382

Histological changes of tongue papillae induced by the artificial sweetener Aspartame and the protective effect of Platelet-rich plasma

Egyptian Dental Journal
Article 14, Volume 64, Issue 2 - April (Oral Medicine, X-Ray, Oral Biology & Oral Pathology), April 2018, Page 1275-1282  XML PDF (1.6 MB)
Document Type: Original Article
DOI: 10.21608/edj.2018.77382
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Authors
Dalia H. Zahran1; Elham F. Mahmoud2; Mahmoud F. Mahmoud3
1Associate Professor of Oral Biology, Faculty of Dentistry, Tanta University, Egypt
2Associate Professor of Oral Biology, Faculty of Oral and Dental Medicine, Suez Canal University, Egypt.
3Associate Professor, Department of Biological and Geological Sciences, Faculty of Education, Ain Shams University, Egypt,
Abstract
Aspartame (ASP) is one of the most controversial food additives found in various food products all over the world. Once ingested, ASP is metabolized to phenylalanine, aspartic acid, and methanol. The aims of the study are to evaluate the effects of ASP administration on the dorsal surface of rats’ tongues and to investigate the possible protective effect of Platelet-rich plasma (PRP). Thirty adult male albino rats were used and divided into three equal groups. The control group received the vehicle only. ASP group received a dose of 250 mg/kg b wt for four weeks while the PRP group were treated as ASP group, in addition they received a single local injection with PRP in the right lateral border of the tongue. The most obvious changes were loss of normal conical appearance with hyperkeratosis of filiform papillae. The epithelial cells showed hyperplasia (acanthosis), cellular pleomorphism and nuclear hyperchromatism. Distorted and atrophied fungiform papilla with degeneration of epithelial cells and pyknotic nuclei were visible. In the lamina propria numerous dilated and congested blood vessels were obvious. SEM examination revealed disfigurement of tongue papillae. The fungiform papillae showed irregular wrinkled surface and ill-defined taste pore. PRP treatment almost restored the normal architecture of tongue papillae. Chronic aspartame ingestion could result in marked morphological alteration of dorsal surface of the tongue and PRP exerted a protective role against this effect.
Keywords
Aspartame; platelet-rich plasma; tongue papillae; rat
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