Effects of Moringa Oleifera Aqueous Leaf Extract on Submandibular Salivary Glands of Diabetic Albino Rats | ||||
Egyptian Dental Journal | ||||
Article 16, Volume 64, Issue 2 - April (Oral Medicine, X-Ray, Oral Biology & Oral Pathology), April 2018, Page 1293-1303 PDF (3.74 MB) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/edj.2018.77385 | ||||
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Authors | ||||
Radwa T. El-sharkawy1; Hala A. El-kammar2; Raneem F. Obeid2; Abdelfattah A. Bdelkhalek3 | ||||
1Lecturer of Oral Histology, Faculty of Oral and Dental Medicine, Future University in Egypt | ||||
2Lecturer of Oral Pathology, Faculty of Oral and Dental Medicine, Future University in Egypt | ||||
3Lecturer of Microbiology, General Science Department, Faculty of Oral and Dental Medicine, Future University in Egypt | ||||
Abstract | ||||
Moringa Oleifera (MO), also known as the ‘drumstick tree,’ is recognized as a nutritious and cheap source of phytochemicals, that a have a prominent anti-oxidative effect. Salivary gland dysfunction has been frequently reported in diabetic patients. Diabetes is a chronic metabolic disease that has complications mainly resulting from persistent hyperglycemia. Aim of the study: To Assess the effect of MO aqueous leaf extract on blood glucose levels in diabetic albino rats and its effect on submandibular salivary glands of diabetic albino rats. Materials and methods: the study comprised three groups; control, diabetic and MO treated groups. The experiment was terminated after fourteen days. The evaluation was performed by measuring the blood glucose levels and weight. Histological evaluation was done by H&E, PAS and IHC for COX-2. Results: the blood glucose levels and histological signs of diabetic complications were significantly lowered in the MO treated group. Conclusion: MO is a promising anti-diabetic treatment and may even reverse some of the diabetic complications. | ||||
Keywords | ||||
COX-2; diabetes; Moringa oleifera; Reactive oxygen species; Submandibular salivary gland | ||||
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