ASSESSMENT OF THE EFFECTOR ANTIBODIES AGAINST SCHISTOSOMA MANSONI AND THEIR IMPACT ON MEFLOQUINE EFFICACY | ||||
| Journal of the Egyptian Society of Parasitology | ||||
| Article 20, Volume 48, Issue 1, April 2018, Page 175-181 PDF (387.12 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/jesp.2018.77485 | ||||
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| Authors | ||||
| SHAIMAA H. EL-SAYED1; HEBAT-ALLAH S. A. YOUSOF2; MONA M. M. KHATER2 | ||||
| 1Departments of Medical Parasitology, Faculty of Medicine, Helwan University, Egypt. | ||||
| 2Departments of Medical Parasitology, Faculty of Medicine, Cairo University, Cairo, Egypt. | ||||
| Abstract | ||||
| Host immune response against Schistosoma mansoni is a major contributor in the process of resistance or susceptibility to re-infection, as well as the therapeutic response towards different antischistosomal drugs. This study evaluated the role of IgG &IgG4 as immune-logical marker of cure and their effect on anti-schistosomal mefloquine efficacy. Sixty Swiss albino mice were infected with Schistosoma cercaria and divided into four groups; non-infected, infected not treated, infected treated with praziquantel and infected treated with mefloquine. The effect of drugs was assessed parasitologically using Kato-Katz technique and immunologically by measuring the serum level of anti-Schistosoma IgG & IgG4 subclass. The results showed 83.5% significant egg count reduction in MFQ-treated infected group. Also, serum anti-soluble egg antigen (SEA) total IgG & IgG4 subclass levels in MFQ treated group were significantly different from infected control group & PZQ-treated infected group. | ||||
| Keywords | ||||
| Schistosoma mansoni; Mefloquine; Kato-Katz; antischistosomal IgG & IgG4 | ||||
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