IMPACT OF DIABETIC CONTROL ON ACHIEVING SUSTAINED VIROLOGIC RESPONSE IN CHRONIC HCV PATIENTS RECEIVING DIRECT-ACTING ANTIVIRALS | ||||
| Journal of the Egyptian Society of Parasitology | ||||
| Article 23, Volume 48, Issue 1, April 2018, Page 207-2013 PDF (291.93 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/jesp.2018.77498 | ||||
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| Authors | ||||
| KHALED ELKARMOUTY; REHAM AL-SWAFF; AYMAN GAMIL; AHMED ALI MOHAMMED | ||||
| Department of Internal Medicine, Faculty of Medicine, Ain Shams University, Cairo 11566, Egypt. | ||||
| Abstract | ||||
| This study evaluated the effect of diabetic control on achieving sustained virologic response in patients with chronic hepatitis C virus infection who received direct-acting antivirals (Daclatasvir + Sofosbuvir ± Ribavirin). It included 100 patients with chronic HCV infection (Treatment naive patients). Patients were classified into 3 groups according to diabetic control; GI: non diabetics, GII: well controlled diabetics & GIII: poorly controlled diabetics. All were subjected to clinical and laboratory examinations, abdominal ultrasonography and calculation of FIB-4 score. PCR for HCV RNA was assessed prior to treatment, post treatment and 12 weeks post-treatment. The results showed insignificant differences between all groups as regards sustained virologic response. Overall sustained virologic response was achieved in 91% of patients including 91.8% of patients treated with Daclatasvir + Sofosbuvir and 89.7% of those treated with Daclatasvir + Sofosbuvir + Ribavirin. | ||||
| Keywords | ||||
| hepatitis C; type-2 DM; diabetic control; direct-acting antivirals | ||||
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