Some pharmacological studies of cephradine in broilers | ||||
| Journal of Veterinary Medical Research | ||||
| Article 4, Volume 20, Issue 2, March 2010, Page 25-30 PDF (565.17 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/jvmr.2020.77647 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| A.A.M. El-Gendy; Abeer M. Radi; M.A. Tohamy | ||||
| Pharmacology Department, Faculty of Veterinary Medicine, Beni-Suef University | ||||
| Abstract | ||||
| The pharmacokinetic aspects of cephradine were studied after intravenous (IV), intramuscular (IM), subcutaneous (SC) and oral administration of a single dose of 50 mg kg-1 b.wt. in chickens. Tissue distribution and residues of cephradine after repeated oral administration for 5 consecutive days were also estimated. After IV injection of cephradine in a dose of 50 mg kg-1 b.wt., the serum concentration time curves were best described by a two compartment-open model. The drug was rapidly distributed with a distribution half-life (t0.5(α)) of 0.120 h and apparent volume of distribution (Vdss) was 2.187 L kg-1. The drug was rapidly eliminated with a half-life of elimination (t0.5(β)) of 1.047 h and the body clearance (ClB) was 2.35 L kg-1 h-1. The drug was rapidly absorbed after IM, SC and oral administration as indicated by short half-lives of absorption (t0.5(ab)) of 0.154, 0.364 and 0.65 h., respectively. While the elimination half-lives (t0.5(el)) and systemic bioavailabilities were 0.859, 2.652, 1.74 h and 59.386, 84.5, 97.97 %, respectively. Repeated oral administration of cephradine (50 mg kg-1 b.wt twice daily) for 5 consecutive days caused no change in serum enzyme activities of ALT and AST but induced a significant increase in serum uric acid concentration at 72 to 120 hours post administration. | ||||
| Keywords | ||||
| Pharmacological; studies; cephradine; Broilers | ||||
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