THE OUTCOMES OF BONE MARROW STROMAL CELL THERAPY IN SCHISTOSOMAL HEPATIC FIBROSIS: AN EXPERIMENTAL STUDY
ABOU RAYIA, D., ELMARHOUMY, S., ISMAIL, H., ELCHENNAWY, F., ZALATA, K. (2017). THE OUTCOMES OF BONE MARROW STROMAL CELL THERAPY IN SCHISTOSOMAL HEPATIC FIBROSIS: AN EXPERIMENTAL STUDY. EKB Journal Management System, 47(3), 633-642. doi: 10.21608/jesp.2017.77722
DINA M. ABOU RAYIA; SIRRIA M. ELMARHOUMY; HOWAIDA H. ISMAIL; FARHA A. ELCHENNAWY; KHALED R. ZALATA. "THE OUTCOMES OF BONE MARROW STROMAL CELL THERAPY IN SCHISTOSOMAL HEPATIC FIBROSIS: AN EXPERIMENTAL STUDY". EKB Journal Management System, 47, 3, 2017, 633-642. doi: 10.21608/jesp.2017.77722
ABOU RAYIA, D., ELMARHOUMY, S., ISMAIL, H., ELCHENNAWY, F., ZALATA, K. (2017). 'THE OUTCOMES OF BONE MARROW STROMAL CELL THERAPY IN SCHISTOSOMAL HEPATIC FIBROSIS: AN EXPERIMENTAL STUDY', EKB Journal Management System, 47(3), pp. 633-642. doi: 10.21608/jesp.2017.77722
ABOU RAYIA, D., ELMARHOUMY, S., ISMAIL, H., ELCHENNAWY, F., ZALATA, K. THE OUTCOMES OF BONE MARROW STROMAL CELL THERAPY IN SCHISTOSOMAL HEPATIC FIBROSIS: AN EXPERIMENTAL STUDY. EKB Journal Management System, 2017; 47(3): 633-642. doi: 10.21608/jesp.2017.77722

THE OUTCOMES OF BONE MARROW STROMAL CELL THERAPY IN SCHISTOSOMAL HEPATIC FIBROSIS: AN EXPERIMENTAL STUDY

Journal of the Egyptian Society of Parasitology
Article 18, Volume 47, Issue 3, December 2017, Page 633-642  XML PDF (506.87 K)
Document Type: Original Article
DOI: 10.21608/jesp.2017.77722
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Authors
DINA M. ABOU RAYIA1; SIRRIA M. ELMARHOUMY1; HOWAIDA H. ISMAIL1; FARHA A. ELCHENNAWY2; KHALED R. ZALATA3
1Department of Parasitology, Faculty of Medicine, Tanta University, Egypt.
2Department of Clinical Pathology, Faculty of Medicine, Mansoura University, Egypt.
3Department of Histopathology, Faculty of Medicine, Mansoura University, Egypt.
Abstract
Liver fibrosis is considered a serious health problem. Liver transplantation is almost the only curative treatment. The limited number of donors and the post-operative complications are major obstacles. Recent reports have shown that mesenchymal stem cells could improve chemically- induced hepatic fibrosis. The purpose of the present study was to evaluate the effect of bone marrow stromal cells (BMSCs) transplantation on hepatic fibrosis in Schistosoma mansoniinfected mice. Female mice infected with S. mansoni were divided into three test groups. One group received praziquantel drug orally. Another group received BMSCs, obtained from male mice, by intravenous injection. The last group received both. Two control groups were used, one was infected and untreated and the other was uninfected and untreated. Detection of BMSCs hepatic engraftment, morphometric analysis and histopathological evaluation of liver fragments, were done. Level of interleukin-10 (IL-10) mRNA expression was assessed. The results showed that BMSCs engrafted into the liver. There was significant improvement in morphometric and histopathological evaluation of liver fragments, and increase in IL-10 mRNA expression of all treated modalities. Promising result was achieved when BMSCs and PZQ used in treated mice.
Keywords
stem cells; Bone marrow stromal cells; Mesenchymal Stem Cells; Schistosoma mansoni; Schistosomiasis; Liver fibrosis
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