ROLE OF OXIDIZED LOW-DENSITY LIPOPROTEIN IN HEPATITIS C RELATED CHRONIC LIVER DISEASE | ||||
| Journal of the Egyptian Society of Parasitology | ||||
| Article 20, Volume 47, Issue 3, December 2017, Page 653-662 PDF (399.44 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/jesp.2017.77725 | ||||
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| Authors | ||||
| MAHMOUD ABU EL-MAKAREM1; ABDEL-AZIZ ABDEL-RAHMAN EL-NOKALY2; SAYED FAROUK MOHAMED3 | ||||
| 1Department of Medical Biochemistry, Faculty of Medicine, AL-Azhar University. | ||||
| 2Department of Medical Biochemistry, Faculty of Medicine, AL-Azhar University | ||||
| 3Department of Tropical Medicine, Faculty of Medicine, AL-Azhar University | ||||
| Abstract | ||||
| Hepatitis C virus(HCV) lifecycle is closely connected to host cell lipid metabolism, inducing oxidative stress and oxidation reaction induce chemical modification of proteins and lipids in plasma LDL transforming it to abnormal oxidized-LDL (Ox-LDL). Ox-LDL is more stable marker molecule with longer half-life than free radicals. This study assessed its contribution to the pathogenesis of liver diseases, and liver cirrhosis. This work studied serum level of ox-L L to evaluate its role in chronic hepatitis C patients and its association with liver cirrhosis. Also, the level of serum total antioxidant status was determined to evaluate their role in the treatment. The study included 20 chronic hepatitis C patients, 20 chronic hepatitis C patients with liver cirrhosis and 20 controls (age, sex & anthropometric measures were matched). All patients and controls were males. Serum was used to estimate Ox-LDL total direct bilirubin, albumin, aminotransferases, total antioxidant capacity, Urea and creatinine. | ||||
| Keywords | ||||
| Egypt; patients; HCV; Chronic liver disease; Ox-LDL; TAC | ||||
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