Some pharmacodynamic interactions between salinomycin and vitamin E or selenium in chickens
El-Sadek, S., Tohamy, M., A. El-Badry, A., Fouad, N., El-Gendy, A. (2009). Some pharmacodynamic interactions between salinomycin and vitamin E or selenium in chickens. EKB Journal Management System, 19(2), 24-32. doi: 10.21608/jvmr.2009.77814
S.E. El-Sadek; M. A. Tohamy; Abeer A. El-Badry; Noha A. M. Fouad; A. A. M. El-Gendy. "Some pharmacodynamic interactions between salinomycin and vitamin E or selenium in chickens". EKB Journal Management System, 19, 2, 2009, 24-32. doi: 10.21608/jvmr.2009.77814
El-Sadek, S., Tohamy, M., A. El-Badry, A., Fouad, N., El-Gendy, A. (2009). 'Some pharmacodynamic interactions between salinomycin and vitamin E or selenium in chickens', EKB Journal Management System, 19(2), pp. 24-32. doi: 10.21608/jvmr.2009.77814
El-Sadek, S., Tohamy, M., A. El-Badry, A., Fouad, N., El-Gendy, A. Some pharmacodynamic interactions between salinomycin and vitamin E or selenium in chickens. EKB Journal Management System, 2009; 19(2): 24-32. doi: 10.21608/jvmr.2009.77814

Some pharmacodynamic interactions between salinomycin and vitamin E or selenium in chickens

Journal of Veterinary Medical Research
Article 4, Volume 19, Issue 2, March 2009, Page 24-32  XML PDF (1.02 MB)
Document Type: Original Article
DOI: 10.21608/jvmr.2009.77814
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Authors
S.E. El-Sadek1; M. A. Tohamy1; Abeer A. El-Badry2; Noha A. M. Fouad3; A. A. M. El-Gendy1
1Deparment of Pharmacology, Faculty of Veterinary Medicine, Beni-Suef University, Beni-Suef 62511, Egypt
2Animal Health Research Institute, Qena, Egyp
3nimal Health Research Institute, Qena, Egypt.
Abstract
The present study was conducted to determine the effect of salinomycin at a concentration 60 and 120 ppm alone and with vitamin E or selenium on haematological and biochemical parameters and histopathological changes of the treated chicken. Salinomycin (120 ppm) induced decrease in body weight, feed consumption and feed conversion efficiency. In addition, when salinomycin (120 ppm) given with vitamin E, the body performance improved significantly, but when sodium selenite used, body performance significantly decreased. Salinomycin at concentration 120 ppm induced decrease in blood parameters (RBCs count, TLC count, Hb content and PCV %). Concurrent use of vitamin E with salinomycin leads to improvement of these parameters. Salinomycin at 120 ppm induced significant increase in enzymes activities (ALT and AST). The uses of vitamin E with slinomycin (120 ppm) caused significant decrease in these activities. In contrast to selenium, which reduce the activity of AST enzyme only. Salinomycin at 120 ppm decreased the total protein concentration and increased the level of creatinine and uric acid. Concurrent administrations of vitamin E or selenium with salinomycin have no effect on these parameters. At 120 ppm salinomycin, selenium increased the creatinine concentration in blood serum. The drug at 60 or 120 ppm induced various pathological changes in certain tissues (liver, heart, kidney and skeletal muscle) ranged from degeneration to necrosis of these tissues. Concurrent administration of salinomycin with vitamin E or selenium revealed that vitamin E decreased the pathological changes of studied tissues.
Keywords
pharmacodynamic; interactions; salinomycin; Vitamin E; chickens
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