Is Oral Anticoagulant with High dose in Pregnant Women with Prosthetic Mechanical Valve Effective and Safe? | ||||
Zagazig University Medical Journal | ||||
Article 11, Volume 26, Issue 3, May 2020, Page 450-454 PDF (592.9 K) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/zumj.2020.23331.1717 | ||||
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Authors | ||||
Mohammad Eltahlawi ![]() ![]() | ||||
1Cardiology Department, Faculty of Medicine, Zagazig University | ||||
2Department of Cardiothoracic surgery, Faculty of Medicine, Zagazig University | ||||
3Cardiothoracic Surgery, Faculty of Medicine, Zagazig University | ||||
4Department of Anatomy & Emberyology, Faculty of Medicine, Zagazig University | ||||
Abstract | ||||
Background: The management of women with prothetic valves in pregnancy remains challenging. Anticoagulation in these subgroups has many controversies. Aim: We aim to evaluate the safety dose of oral anticoagulant in pregnant women with mechanical valve prosthesis in first trimester. Patients &Methods: Pregnant ladies with well functioning prothetic valves were enrolled. Patients were divided into 3 groups: Group A took oral anticoagulant < 5 mg warfarin with therapeutic INR. Group B took low molecular weight heparin (LMWH) twice daily and monitoring is done every week by antifactorXa 4-6 hours post-injection to keep about 1 IU/ml. Group C took oral anticoagulant in dose > 5 mg warfarin to reach therapeutic INR. Results: There was significant difference between groups in vaginal bleeding and abortion, with more bleeding and abortion in group Busing LMWH. There was a high rate of malfunction valve about 19.9% in group B, but no reportedcases of malfunction valve in the other both groups using warfarin. Conclusion: Warfarin with dose > 5 mg in pregnant women with mechanical prosthetic valve is as safe for mother and baby as warfarin with dose < 5 mg. Both regimens are safer than LMWH. | ||||
Keywords | ||||
Oral anticoagulant; Warfarin; Pregnancy; Prothetic valve; Teratogenic | ||||
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