Clinicopathological studies on experimentally infected rabbits with bovine herpesvirus -1
Sayed, W., Kamel, H., Abd-El-Rahman, A., El-Nesr, K., Madbouly, H., Mohamed, A. (2005). Clinicopathological studies on experimentally infected rabbits with bovine herpesvirus -1. EKB Journal Management System, 15(2), 25-33. doi: 10.21608/jvmr.2005.77927
Walaa M. Sayed; H. H. Kamel; Azza H. Abd-El-Rahman; K. A. El-Nesr; H. M. Madbouly; Amira H. Mohamed. "Clinicopathological studies on experimentally infected rabbits with bovine herpesvirus -1". EKB Journal Management System, 15, 2, 2005, 25-33. doi: 10.21608/jvmr.2005.77927
Sayed, W., Kamel, H., Abd-El-Rahman, A., El-Nesr, K., Madbouly, H., Mohamed, A. (2005). 'Clinicopathological studies on experimentally infected rabbits with bovine herpesvirus -1', EKB Journal Management System, 15(2), pp. 25-33. doi: 10.21608/jvmr.2005.77927
Sayed, W., Kamel, H., Abd-El-Rahman, A., El-Nesr, K., Madbouly, H., Mohamed, A. Clinicopathological studies on experimentally infected rabbits with bovine herpesvirus -1. EKB Journal Management System, 2005; 15(2): 25-33. doi: 10.21608/jvmr.2005.77927

Clinicopathological studies on experimentally infected rabbits with bovine herpesvirus -1

Journal of Veterinary Medical Research
Article 4, Volume 15, Issue 2, March 2005, Page 25-33  XML PDF (624.32 K)
Document Type: Original Article
DOI: 10.21608/jvmr.2005.77927
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Authors
Walaa M. Sayed1; H. H. Kamel1; Azza H. Abd-El-Rahman1; K. A. El-Nesr2; H. M. Madbouly3; Amira H. Mohamed4
1Department of Clinical Pathology, Faculty of Veterinary Medicine, Beni-Suef University, Beni-Suef, Egypt
2Department of Pathology, Faculty of Veterinary Medicine, Beni-Suef University, Beni-Suef, Egypt
3Department of Virology, Faculty of Veterinary Medicine, Beni-Suef University, Beni-Suef, Egypt
4Department of Clinical Pathology, Faculty of Veterinary Medicine, Cairo University, Cairo, Egypt
Abstract
Forty-eight pathogen free New Zealand rabbits were divided into two groups, the first group contained eighteen rabbits served as normal control and the second group of thirty rabbits were received 1 ml bovine herpesvirus-1 (BHV-1) virus suspension (107 TCID 50) by intraperitoneal route. Rabbits both groups were subjected to hematological, serum biochemical, different serological and  histopathological examination 3,7,10,14,21 and 28 days post infection. Clinical observation of infected rabbits showed febrile response and mild conjunctivitis after 24 and 48h. of inoculation, respectively. The hemogram revealed no significant alteration in the erythrogram while leucogram showed leucocytosis accompanied with heterophilia, lymphopenia and monocytopenia at the 3rd and 7th days post infection. Serum biochemical analysis showed significant elevation in the activity of AST, ALT and AP and in blood urea nitrogen and creatinine concentration along the experimental period. Serum total proteins, albumin, :, ; and < globulin significantly increased at different periods of the experiment. BHV-1 antibodies were detected in the sera of infected rabbits by Dot ELISA and ELISA from the first week until the forth week post infection. Histopathological examination revealed that the most affected organs were the trachea, lungs and liver while adrenals, kidneys, and spleen showed mild pathological alterations.
Keywords
Clinicopathological Studies; Rabbits; infected; bovine; Herpesvirus
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