BEE VENOM LOADED CHITOSAN NANOPARTICLES AS TREATMENT FOR AMOEBIASIS IN MICE
SABER, A., ABDELWAHAB, A., EL AMIR, A., NASSAR, M., ZOHDI, H. (2017). BEE VENOM LOADED CHITOSAN NANOPARTICLES AS TREATMENT FOR AMOEBIASIS IN MICE. EKB Journal Management System, 47(2), 443-458. doi: 10.21608/jesp.2017.77951
AMANY EL SAYED SABER; ABDELWAHAB KHALIL ABDELWAHAB; AZZA MOHAMED EL AMIR; MAMDOUH IBRAHIM NASSAR; HUSSEIN FOUAD ZOHDI. "BEE VENOM LOADED CHITOSAN NANOPARTICLES AS TREATMENT FOR AMOEBIASIS IN MICE". EKB Journal Management System, 47, 2, 2017, 443-458. doi: 10.21608/jesp.2017.77951
SABER, A., ABDELWAHAB, A., EL AMIR, A., NASSAR, M., ZOHDI, H. (2017). 'BEE VENOM LOADED CHITOSAN NANOPARTICLES AS TREATMENT FOR AMOEBIASIS IN MICE', EKB Journal Management System, 47(2), pp. 443-458. doi: 10.21608/jesp.2017.77951
SABER, A., ABDELWAHAB, A., EL AMIR, A., NASSAR, M., ZOHDI, H. BEE VENOM LOADED CHITOSAN NANOPARTICLES AS TREATMENT FOR AMOEBIASIS IN MICE. EKB Journal Management System, 2017; 47(2): 443-458. doi: 10.21608/jesp.2017.77951

BEE VENOM LOADED CHITOSAN NANOPARTICLES AS TREATMENT FOR AMOEBIASIS IN MICE

Journal of the Egyptian Society of Parasitology
Article 24, Volume 47, Issue 2, August 2017, Page 443-458  XML PDF (1.76 MB)
Document Type: Original Article
DOI: 10.21608/jesp.2017.77951
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Authors
AMANY EL SAYED SABER1; ABDELWAHAB KHALIL ABDELWAHAB2; AZZA MOHAMED EL AMIR3; MAMDOUH IBRAHIM NASSAR4; HUSSEIN FOUAD ZOHDI1
1Department of Chemistry, Faculty of Science, Cairo University, Giza, Egypt.
2Department of Zoology, Faculty of Science, Beni-Suef University, Beni-Suef, Egypt.
3Department of Zoology, Faculty of Science, Cairo University,Giza, Egypt.
4Department of Entomology, Faculty of Science, Cairo University, Giza, Egypt.
Abstract
Entamoeba histolytica is an invasive parasite and results in intestinal inflammation and amebic liver abscess. Metronidazole is the main used drug for amoebiasis in both adults and children. However, metronidazole has some drawbacks such as having potential mutagenic effects in rats as well as the problem of the emergence of drug- resistance species makes the development of other safer drugs for amoebiasis is critical. In this study we assessed the ability of bee venom (BV) loaded chitosan (CS) nanoparticles to treat amoebiasis and that BV has antiamoebic effect as well as it is proved that orally administered BV loaded CS nanoparticles can be a more effective alternative drug for amoebiasis than subcutaneously injected BV.
Keywords
Amoebiasis; Bee venom; Chitosan nanoparticles
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