THE EFFECT OF THE TRAMADOL ACCUMULATED IN RAT LIVER ON THE DEVELOPMENT OF THE IMMATURE STAGES OF THE FLESH FLY SARCOPHAGA ARGYROSTOMA (ROBINEAU-DESVOIDY, 1830) (DIPTERA: SARCOPHAGIDAE) | ||||
Journal of the Egyptian Society of Parasitology | ||||
Article 7, Volume 47, Issue 1, April 2017, Page 55-64 PDF (494.37 K) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/jesp.2017.77973 | ||||
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Authors | ||||
IBRAHIM F. TAHOUN1; EHAB M. ABOUZIED2 | ||||
1National Institute of Standards, Tersa St, El-Matbah, Haram, P. O. Box: 136, Code No: 12211 Giza, Egypt. | ||||
2Department of Zoology, Faculty of Science, P.O. Box: 63514, Fayoum University, Al-Fayoum, Egypt. | ||||
Abstract | ||||
The present study investigated the effects of the accumulation of tramadol on the development rates of the larvae and pupae. Larvae of the flesh fly Sarcophaga argyrostoma (Robineau-Desvoidy, 1830) were reared on three groups of Wister albino rat livers. One group was administere the recommended or normal dose (D1) and the second group was injected with higher over or double dose (D2) of tramadol. Tramadol was administered by stomach tube once a day, for 3 months. The third group was injected with normal saline solution as the control. Using GC-Ms analysis, Rat livers contained 0.72 and 1.62mg/g of tramadol, in case of D1 and D2, respectively. Larvae of S. argyrostoma fed on D1 and D2 rat livers contained (0.11 & 0.18mg/g), respectively. The corresponding tramadol concentrations persisted in the produced pupae of S. argyrostoma were (0.07 & 0.09mg/g), respectively. The accumulation of tramadol in tissues of S. argyrostoma larvae reduced the durations of larval stadia from (7.0408±1.0198 days) in case of the control to (6.6383±0.4857 days) when fed on D1 liver and (6.3438±0.4826 days) when fed on D2 livers. The pupal durations was altered to (14.3750±0.4919 days) for D2 and (14.9574±0.6580 days) for D1, compared to (13.9167±1.0071 days), in case of the control. The average weight of the 3rd day larva of S. argyrostoma decreased from 18.1807±1.4949mg, in case of the control to 14.7279±1.3366mg and 14.9560±3.8210mg, when fed on D1 and D2 tramadol treated livers. In contrast, corresponding weight produced pupae increased from 14.1750±0.4667mg (control) to 15.2449±0.302mg & 15.9062±0.2888mg, in case of D1 and D2, respectively. | ||||
Keywords | ||||
Sarcophagidae; Larvae; Development; tramadol; Flesh flies; Rat liver | ||||
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