Preparation and evaluation of combined inactivated vaccine containing rota, corona viruses, Escherichia coli bacterin and Clostridium perfringens type Ctoxoid (Entero-4)
Daoud, A., Diab, R., Aboul Saoud, S., Zeidan, S., Zaki, F. (2005). Preparation and evaluation of combined inactivated vaccine containing rota, corona viruses, Escherichia coli bacterin and Clostridium perfringens type Ctoxoid (Entero-4). EKB Journal Management System, 15(2), 232-237. doi: 10.21608/jvmr.2005.77994
A. M. Daoud; R. A. Diab; S. M. Aboul Saoud; S. M. Zeidan; F. F. Zaki. "Preparation and evaluation of combined inactivated vaccine containing rota, corona viruses, Escherichia coli bacterin and Clostridium perfringens type Ctoxoid (Entero-4)". EKB Journal Management System, 15, 2, 2005, 232-237. doi: 10.21608/jvmr.2005.77994
Daoud, A., Diab, R., Aboul Saoud, S., Zeidan, S., Zaki, F. (2005). 'Preparation and evaluation of combined inactivated vaccine containing rota, corona viruses, Escherichia coli bacterin and Clostridium perfringens type Ctoxoid (Entero-4)', EKB Journal Management System, 15(2), pp. 232-237. doi: 10.21608/jvmr.2005.77994
Daoud, A., Diab, R., Aboul Saoud, S., Zeidan, S., Zaki, F. Preparation and evaluation of combined inactivated vaccine containing rota, corona viruses, Escherichia coli bacterin and Clostridium perfringens type Ctoxoid (Entero-4). EKB Journal Management System, 2005; 15(2): 232-237. doi: 10.21608/jvmr.2005.77994

Preparation and evaluation of combined inactivated vaccine containing rota, corona viruses, Escherichia coli bacterin and Clostridium perfringens type Ctoxoid (Entero-4)

Journal of Veterinary Medical Research
Article 38, Volume 15, Issue 2, March 2005, Page 232-237  XML PDF (150.6 K)
Document Type: Original Article
DOI: 10.21608/jvmr.2005.77994
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Authors
A. M. Daoud1; R. A. Diab1; S. M. Aboul Saoud1; S. M. Zeidan1; F. F. Zaki2
1Veterinary Serum and Vaccine Research Institute, Abbassia, Cairo, Egypt
2Central Laboratory for Evaluation of Veterinary Biologics, Abbassia, Cairo, Egypt
Abstract
A conclusive study was conducted for preparation and evaluation of combined inactivated entero-4 vaccine containing bovine rotavirus (BRV), bovine coronavirus (BCV), E. coli K99 and toxoid of C. perfringens type "C". Laboratory and field evaluations were conducted on laboratory animals, calves and late pregnant cows with monitoring the active and passive antibodies in vaccinated cows and their offspring respectively. Laboratory evaluation proved purity, safety and high efficacy of the vaccine without interference between different vaccine ingredients. Field evaluation gave satisfactory results when pregnant cows vaccinated at late stage of pregnancy with high neutralizing antibody titers against BRV, BCV and C. perfringens as well as high E. coli agglutinating titers. Maternal immunity passively protected offspring during the critical period of age and remained protected till the end of sampling time (30th day post parturition).
Keywords
Preparation; Evaluation; vaccine; inactivated; corona; viruses; Escherichia coli; bacterin; toxoid
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