HISTOPATHOLOGICAL ANALYSIS OF SCHISTOSOMA HAEMATOBIUM METAPLASIA OF THE URINARY BLADDER | ||||
| Journal of the Egyptian Society of Parasitology | ||||
| Article 24, Volume 47, Issue 1, April 2017, Page 211-218 PDF (751.68 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/jesp.2017.78037 | ||||
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| Authors | ||||
| NOHA S. AHMED1; SHEREN F. MAHMOUD2; ELNISR R. MOHAMED3; REFAAT M. KHALIFA4 | ||||
| 1Departments of Medical Parasitology, Faculty of Medicine, Sohag University, Sohag, Egypt. | ||||
| 2Departments of Pathology, Faculty of Medicine, Sohag University, Sohag, Egypt. | ||||
| 3Departments of Urology, Faculty of Medicine, Sohag University, Sohag, Egypt. | ||||
| 4Department of Medical Parasitology, Assiut University, Assiut , Egypt. | ||||
| Abstract | ||||
| The present cross sectional study was carried out to analyze the histopathological changes in the urinary bladder affected by Schistosoma haematobium among 54 patients (aged between 20-60 years; 40 males, 14 females; 44 from rural, 10 from urban areas) attending Sohag University Hospital, Egypt from October 2015 to March 2016. 10% formalin fixed biopsy specimens were examined from which sections of 5 μm were prepared and examined microscopically. Mid-stream urine samples were collected from the patients after a slight physical exercise immediately transported to the Parasitological Laboratory to be examined for S. haematobium eggs. Histopathological examination revealed squamous metaplasia of the urinary bladder in 38/54 cases (70.4%); 20/54 (37%) non- keratinizing metaplasia, 18/54 (33.3%) keratinizing metaplasia and invasive squamous carcinoma in 11/54 (20.4%). It was concluded that Schistosoma haematobium is still one of the major risks of developing squamous cell metaplasia of the urinary bladder in Egypt which was found to be of high statistically significance in both males and females in rural areas. In this study, bladder squamous metaplasia was subdivided into non-keratinizing with less malignant potential, keratinizing with a definite affinity to carcinogenesis and invasive severe forms; but these subdivisions were found to be statistically not significant in relation to gender, age and locality, although they were of importance for the proper and successful management of the encountered cases. | ||||
| Keywords | ||||
| Schistosoma haematobium; histopathology; Urinary bladder; Squamous metaplasia | ||||
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