Bioactive Components and Hepatoprotective Activity of Acanthopleura vaillantii (Chiton) against Carbon Tetrachloride-Induced Hepatotoxicity in Mice
Khalil, E., Swelim, H., Abdullah, M. (2020). Bioactive Components and Hepatoprotective Activity of Acanthopleura vaillantii (Chiton) against Carbon Tetrachloride-Induced Hepatotoxicity in Mice. EKB Journal Management System, 12(1), 39-48. doi: 10.21608/eajbsd.2020.78189
Eman Khalil; Hamdy Swelim; Mohd Azmuddin Abdullah. "Bioactive Components and Hepatoprotective Activity of Acanthopleura vaillantii (Chiton) against Carbon Tetrachloride-Induced Hepatotoxicity in Mice". EKB Journal Management System, 12, 1, 2020, 39-48. doi: 10.21608/eajbsd.2020.78189
Khalil, E., Swelim, H., Abdullah, M. (2020). 'Bioactive Components and Hepatoprotective Activity of Acanthopleura vaillantii (Chiton) against Carbon Tetrachloride-Induced Hepatotoxicity in Mice', EKB Journal Management System, 12(1), pp. 39-48. doi: 10.21608/eajbsd.2020.78189
Khalil, E., Swelim, H., Abdullah, M. Bioactive Components and Hepatoprotective Activity of Acanthopleura vaillantii (Chiton) against Carbon Tetrachloride-Induced Hepatotoxicity in Mice. EKB Journal Management System, 2020; 12(1): 39-48. doi: 10.21608/eajbsd.2020.78189

Bioactive Components and Hepatoprotective Activity of Acanthopleura vaillantii (Chiton) against Carbon Tetrachloride-Induced Hepatotoxicity in Mice

Egyptian Academic Journal of Biological Sciences, D. Histology & Histochemistry
Article 5, Volume 12, Issue 1, June 2020, Page 39-48  XML PDF (581.06 K)
Document Type: Original Article
DOI: 10.21608/eajbsd.2020.78189
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Authors
Eman Khalil1; Hamdy Swelim1; Mohd Azmuddin Abdullah2
1Department of Zoology, Faculty of Science, Ain Shams University, Cairo, Egypt
2Institute of Marine Biotechnology, University Malaysia Terengganu, 21030 Kuala Nerus, Terengganu, Malaysia
Abstract
Marine animals provide a wide range of bioactive compounds that may offer new and innovative therapeutic tools for use in various diseases. In this study, the bioactive compounds in the extracts of Acanthopleura vaillantii (chiton) were identified, their antioxidant property assayed and the hepatoprotective activity evaluated in a carbon tetrachloride-induced hepatotoxicity model in mice. The gas chromatography-mass spectrometry (GC-MS) analysis identified mostly the polyphenolic compounds. The antioxidant assay showed that the chiton extract had radical scavenging activity. Intraperitoneal injection of the chiton extract in mice increased the hepatic enzymes and albumin content at the dose level of 10 mg chiton /kg of body weight. While administration of 20 mg chiton extract in mice was with the normalized serum albumin (Alb), alanine aminotransferases (ALT) and aspartate (AST). The histological examination of the liver sections from the 10 and 20 mg chitons treated groups showed substantial attenuation of the degenerative cellular changes, recovery from necrosis and reversal of liver fibrosis induced by the carbon tetrachloride intoxication.
Keywords
Chiton; Acanthopleura vaillantii; Hepatoprotective activity; antioxidant capacity; Carbon tetrachloride
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