Mitigations of Syzygium cummini Fruit Extract on CdCl2 Induced Histopathological Changes in Laboratory Mouse Epididymids
nayat, I., Ahmad, S., Batool, H., Younis, A., Abbas, T., Batool, S., Kanwal, M., Ahmad, K. (2020). Mitigations of Syzygium cummini Fruit Extract on CdCl2 Induced Histopathological Changes in Laboratory Mouse Epididymids. EKB Journal Management System, 12(1), 49-58. doi: 10.21608/eajbsd.2020.78773
Iram nayat; Syeda Nadia Ahmad; Hafsa Batool; Asma Younis; Tahir Abbas; Sajida Batool; Muhammad Ali Kanwal; Khawaja Raees Ahmad. "Mitigations of Syzygium cummini Fruit Extract on CdCl2 Induced Histopathological Changes in Laboratory Mouse Epididymids". EKB Journal Management System, 12, 1, 2020, 49-58. doi: 10.21608/eajbsd.2020.78773
nayat, I., Ahmad, S., Batool, H., Younis, A., Abbas, T., Batool, S., Kanwal, M., Ahmad, K. (2020). 'Mitigations of Syzygium cummini Fruit Extract on CdCl2 Induced Histopathological Changes in Laboratory Mouse Epididymids', EKB Journal Management System, 12(1), pp. 49-58. doi: 10.21608/eajbsd.2020.78773
nayat, I., Ahmad, S., Batool, H., Younis, A., Abbas, T., Batool, S., Kanwal, M., Ahmad, K. Mitigations of Syzygium cummini Fruit Extract on CdCl2 Induced Histopathological Changes in Laboratory Mouse Epididymids. EKB Journal Management System, 2020; 12(1): 49-58. doi: 10.21608/eajbsd.2020.78773

Mitigations of Syzygium cummini Fruit Extract on CdCl2 Induced Histopathological Changes in Laboratory Mouse Epididymids

Egyptian Academic Journal of Biological Sciences, D. Histology & Histochemistry
Article 6, Volume 12, Issue 1, June 2020, Page 49-58  XML PDF (742.45 K)
Document Type: Original Article
DOI: 10.21608/eajbsd.2020.78773
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Authors
Iram nayat1; Syeda Nadia Ahmad1; Hafsa Batool1; Asma Younis1; Tahir Abbas2; Sajida Batool1; Muhammad Ali Kanwal1; Khawaja Raees Ahmad1
1Department of Zoology, University of Sargodha, Sargodha, Punjab, Pakistan
2Department of Biology Government college Sillanwali, District Sargodha, Pakistan
Abstract
The aim of present project was to determine the harmful effects of CdCl2 on epididymis of adult mice (Mus musculus). Histopathological changes in epididymis of mice treated with 50ppm of CdCl2 were studied in this research work. Moreover, remedial effects of Jambul fruit extract were also studied. Study was conducted on 30 male albino mice divided into three groups (n=10) as follows; {(a) Control (C); (untreated); (b) CdCl2 {50ppm CdCl2 as drinking water (15 days) and for natural recovery CdCl2 free water (7days); (c) CdCl2+Jambul extract (CdCl2+J) 50ppm CdCl2 in drinking water for 15 days followed by 0.2mLJambul extract (7days)}. All animals were dissected on day 21st for surgical removal of epididymis. The results revealed that mean tubular cross-sectional area of caput, corpus and cauda epididymis was significantly increased in CdCl2 treated group compared to Control and Cd+J treated groups. A single peritoneal administration of soluble cadmium causes an acute hemorrhagic reaction in proximal end of caput epididymis. The lining epithelium of the proximal caput was atrophied, tubules were dilated and spermatozoa within the lumen were disintegrated.
Keywords
CdCl2; epididymis; histopathology; Syzygium cummini; Mice
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