Residues of Ceftiofur Sodium in Rabbit Tissues | ||||
| Zagazig Veterinary Journal | ||||
| Article 2, Volume 45, Issue 2, June 2017, Page 104-111 PDF (259.04 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/zvjz.2017.7883 | ||||
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| Authors | ||||
Elsayed A. Abdel Aziz1; Sameh M. El-Nabtity1; Abdel Azeem M. El Barawy2; Mohammed A.M. Saleh  2
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| 1Pharmacology Department, Faculty of Veterinary Medicine, Zagazig University, 44511, Egypt | ||||
| 2Animal Health Research Institute, Dokki, Giza, Egypt | ||||
| Abstract | ||||
| This study was designed to determine ceftiofur sodium residues of different rabbit tissues after intramuscular injection at a dose of 2.2 mg/kg BW. A total of twenty-four healthy male New Zealand White rabbits were divided into two groups; the first group (n = 21) was injected with ceftiofur for five successive days, while the second group (n = 3) untreated (control). Liver, kidney, pectoral and thigh muscles, spleen, heart, blood and lung from each rabbit were collected at the 1st, 3rd, 5th, 7th, 9th, 15th and 21st day post ceftiofur sodium treatment. Tissues were extracted and ceftiofur residues were analyzed using high-performance liquid chromatography (HPLC). Ceftiofur remained within the detectable level till the 5th day in most of the investigated tissues (liver, kidney, lung, heart, pectoral and thigh muscles) and serum, but still detected till the 7th and 9th day post treatment in lung and kidney, respectively. It can be concluded that rabbit muscles and livers could be consumed safely at the 3rd day post treatment with that dose, while, rabbit kidneys could be consumed safely at the 1st day post treatment with that dose without any hazards on consumers because the residual level is below the recommended MRL. | ||||
| Keywords | ||||
| ceftiofur; residues; Rabbits; HPLC | ||||
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