The expression of NF-κB in Calcifying odonto genic cysts (COCs) and Ghost cell odonto genic carcinomas (GCOCs)
Ramadan, O., Elnouaem, ,., ElSheikh, S. (2018). The expression of NF-κB in Calcifying odonto genic cysts (COCs) and Ghost cell odonto genic carcinomas (GCOCs). EKB Journal Management System, 64(Issue 4 - October (Oral Medicine, X-Ray, Oral Biology & Oral Pathology)), 3361-3365. doi: 10.21608/edj.2018.78901
Omneya R. Ramadan; , Manal I. Elnouaem; Sahar M. ElSheikh. "The expression of NF-κB in Calcifying odonto genic cysts (COCs) and Ghost cell odonto genic carcinomas (GCOCs)". EKB Journal Management System, 64, Issue 4 - October (Oral Medicine, X-Ray, Oral Biology & Oral Pathology), 2018, 3361-3365. doi: 10.21608/edj.2018.78901
Ramadan, O., Elnouaem, ,., ElSheikh, S. (2018). 'The expression of NF-κB in Calcifying odonto genic cysts (COCs) and Ghost cell odonto genic carcinomas (GCOCs)', EKB Journal Management System, 64(Issue 4 - October (Oral Medicine, X-Ray, Oral Biology & Oral Pathology)), pp. 3361-3365. doi: 10.21608/edj.2018.78901
Ramadan, O., Elnouaem, ,., ElSheikh, S. The expression of NF-κB in Calcifying odonto genic cysts (COCs) and Ghost cell odonto genic carcinomas (GCOCs). EKB Journal Management System, 2018; 64(Issue 4 - October (Oral Medicine, X-Ray, Oral Biology & Oral Pathology)): 3361-3365. doi: 10.21608/edj.2018.78901

The expression of NF-κB in Calcifying odonto genic cysts (COCs) and Ghost cell odonto genic carcinomas (GCOCs)

Egyptian Dental Journal
Article 9, Volume 64, Issue 4 - October (Oral Medicine, X-Ray, Oral Biology & Oral Pathology), October 2018, Page 3361-3365  XML PDF (2.58 MB)
Document Type: Original Article
DOI: 10.21608/edj.2018.78901
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Authors
Omneya R. Ramadan1; , Manal I. Elnouaem2; Sahar M. ElSheikh2
1Lecturer of Oral Pathology, Faculty of Dentistry, University of Alexandria
2Professor of Oral Pathology, Faculty of Dentistry, University of Alexandria
Abstract
Background: Calcifying odontogenic cysts (COCs) are considered rare odontogenic lesions
with a spectrum of behavioral and clinicopathological features. The rare Ghost cell odontogenic
carcinoma (GCOC) is the malignant counterpart of (COC). The goal of this work was to study the
expression NF-κB in COCs and GCOCs.
Methods: NF-κB expression was evaluated in 8 (COCs) and 4 (GCOCs), using
immunohistochemical method. Immunostaining was evaluated semi-quantitatively, following to
the intensity and extent of staining.
Results: B oth cytoplasmic and nuclear and NF-κB immunopositivity were detected in all COC
tissues, as well as in GCOC.
Conclusion: The expression of NF-κB may represent an important mechanism of tumor
development and thus might have a role in the progression of ghost cell lesions.
 
Keywords
Calcifying odontogenic cyst (COC); Nuclear Factor κB; Ghost cell odontogenic carcinoma (GCOC)
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