The synthesis and characterization of gold nanoparticles with polyunsaturated oils contribute to hypolipidemic and anti-obesity activities in vivo.
soliman, A., Abdel-Rahman, M., Hamad, H., Eltamany, E., Al-Sherbini, A. (2020). The synthesis and characterization of gold nanoparticles with polyunsaturated oils contribute to hypolipidemic and anti-obesity activities in vivo.. EKB Journal Management System, 63(11), 4205-4216. doi: 10.21608/ejchem.2020.21510.2280
amira Fawzy soliman; Mohamed A Abdel-Rahman; Hanaa Hamad; Elsayed H Eltamany; Al-Sayed Al-Sherbini. "The synthesis and characterization of gold nanoparticles with polyunsaturated oils contribute to hypolipidemic and anti-obesity activities in vivo.". EKB Journal Management System, 63, 11, 2020, 4205-4216. doi: 10.21608/ejchem.2020.21510.2280
soliman, A., Abdel-Rahman, M., Hamad, H., Eltamany, E., Al-Sherbini, A. (2020). 'The synthesis and characterization of gold nanoparticles with polyunsaturated oils contribute to hypolipidemic and anti-obesity activities in vivo.', EKB Journal Management System, 63(11), pp. 4205-4216. doi: 10.21608/ejchem.2020.21510.2280
soliman, A., Abdel-Rahman, M., Hamad, H., Eltamany, E., Al-Sherbini, A. The synthesis and characterization of gold nanoparticles with polyunsaturated oils contribute to hypolipidemic and anti-obesity activities in vivo.. EKB Journal Management System, 2020; 63(11): 4205-4216. doi: 10.21608/ejchem.2020.21510.2280

The synthesis and characterization of gold nanoparticles with polyunsaturated oils contribute to hypolipidemic and anti-obesity activities in vivo.

Egyptian Journal of Chemistry
Article 5, Volume 63, Issue 11, November 2020, Page 4205-4216  XML PDF (1.26 MB)
Document Type: Original Article
DOI: 10.21608/ejchem.2020.21510.2280
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Authors
amira Fawzy soliman email orcid 1; Mohamed A Abdel-Rahmanorcid 2; Hanaa Hamadorcid 3; Elsayed H Eltamanyorcid 4; Al-Sayed Al-Sherbiniorcid 5
1Department of nutritional chemistry and metabolism, National Nutrition Institute (NNI) - Healthy Minster, Cairo, Egypt
2Assistant Professor of Molecular Toxicology & Physiology of zoology, Zoology Department, Faculty of Science, Suez Canal University, Ismailia, Egypt.
3National institute for nutrition
4Professor of Organic chemistry, Chemistry Department, Faculty of Science, Suez Canal University, Ismailia, Egypt.
5Prof. of Photochemistry and Nano chemistry, Department of Measurements, Photochemistry and Agriculture Applications, National Institute of Laser Enhanced Science (NILES), Cairo University, Giza, Egypt.
Abstract
This study aimed to evaluate the hypolipidemic, and anti-obesity effects of polyunsaturated oils, mixed with gold nanoparticles (AuNPs). AuNPs were prepared by the oleic acid pyrolysis method. The sample was characterized by UV spectroscopy and transmission electron microscope (TEM). Sixty adult male rats were divided into 2 main groups. Group one (n=10 rats) was fed on the healthy diet (serves as basic control). The other group was fed on the high fructose diet (HFD) for four weeks and then was divided into five subgroups. 1st subgroup was fed on HFD only, 2nd and 4th subgroups were treated with n-3 PUFAs oils while 3rd and 5th treated with n-3 PUFAs oils mixed with AuNPs. Treatment of obese rats with n-3 PUFAs mixing with AuNPs revealed a significant decrease in in weight gain accompanied by an improvement of lipid profile. Histological examination of the heart indicated a marked improvement in the architecture and marked decrease of relative weight of heart in treated rats. It may be concluded that mixing of PUFAs oils with AuNPs could have the ability to lower weight gain of obese rats and relieved the various biochemical and histological abnormalities resulted due to obesity metabolic disorders.
Keywords
Obesity; hyperlipidemia; polyunsaturated oils; Nanoparticles
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