Novel anthracene-9-sulfonyl derivatives as anticancer agents: synthesis and in vitro biological evaluation
Salah Goda Elserwy, W., mohammed, N., Kassem, E., Mounier, M., Salah Goda Elserwy, W. (2020). Novel anthracene-9-sulfonyl derivatives as anticancer agents: synthesis and in vitro biological evaluation. EKB Journal Management System, 63(11), 4217-4225. doi: 10.21608/ejchem.2020.24843.2473
Walaa Salah Goda Elserwy; neama mohammed; Emad Kassem; Marwa Mounier; Weam Salah Goda Elserwy. "Novel anthracene-9-sulfonyl derivatives as anticancer agents: synthesis and in vitro biological evaluation". EKB Journal Management System, 63, 11, 2020, 4217-4225. doi: 10.21608/ejchem.2020.24843.2473
Salah Goda Elserwy, W., mohammed, N., Kassem, E., Mounier, M., Salah Goda Elserwy, W. (2020). 'Novel anthracene-9-sulfonyl derivatives as anticancer agents: synthesis and in vitro biological evaluation', EKB Journal Management System, 63(11), pp. 4217-4225. doi: 10.21608/ejchem.2020.24843.2473
Salah Goda Elserwy, W., mohammed, N., Kassem, E., Mounier, M., Salah Goda Elserwy, W. Novel anthracene-9-sulfonyl derivatives as anticancer agents: synthesis and in vitro biological evaluation. EKB Journal Management System, 2020; 63(11): 4217-4225. doi: 10.21608/ejchem.2020.24843.2473

Novel anthracene-9-sulfonyl derivatives as anticancer agents: synthesis and in vitro biological evaluation

Egyptian Journal of Chemistry
Article 6, Volume 63, Issue 11, November 2020, Page 4217-4225  XML PDF (447.59 K)
Document Type: Original Article
DOI: 10.21608/ejchem.2020.24843.2473
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Authors
Walaa Salah Goda Elserwy email orcid 1; neama mohammedorcid 2; Emad Kassem3; Marwa Mounier4; Weam Salah Goda Elserwyorcid 5
1Pharmaceutical Industries Research division Therapeutical Chemistry Department National Research Centre
22Department of Therapeutic Chemistry, Pharmaceutical and Drug Industries Research Division, National Research Centre, Dokki, Cairo, Egypt, 12622.
3Department of Therapeutic Chemistry, National Research Centre, Dokki 12622, Giza, Egypt,
4Pharmaceutical and Drug Industries Research Division, Department of Pharmacognosy, National Research Centre, Giza, Egypt
5Department Of Microbial and Natural Products chemistry National Research Centre
Abstract
In this study, a new series of anthracene-9-sulfonyl derivatives incorporated with different heterocyclic moieties were synthesized and screened for their in vitro anticancer activity against colon carcinoma cell lines (HCT-116), hepatic carcinoma cell lines (HepG 2) and breast carcinoma cell lines (MCF-7). Among them, compound 4-acetylphenyl anthracene-9-sulfonate (8) showed selective high cytotoxic activity over colon carcinoma cell lines (HCT-116), also compounds 2-(anthracen-9-ylsulfonyl)malononitrile (7), N-(4-fluorophenyl)anthracene-9-sulfonamide (5b) and N-((1H-benzo[d]imidazol-2-yl)methyl)anthracene-9-sulfonamide (10) showed the significant selective cytotoxic effect over breast carcinoma cell lines (MCF-7). All the compounds are subjected to explore their safety on normal human skin cell lines (BJ-1), the results revealed that all the compounds are safe and have insignificant weak cytotoxicity over normal human cells.
Keywords
Anthracene; 9; sulfonyl. Anticancer. HCT; 116 cells. HepG 2 cells. MCF; 7 cells
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