Low Level Laser Therapy and Omega-3 in the Management of Recurrent Aphthous Sto matitis | ||||
| Egyptian Dental Journal | ||||
| Article 12, Volume 64, Issue 4 - October (Oral Medicine, X-Ray, Oral Biology & Oral Pathology), October 2018, Page 3391-3405 PDF (1.31 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/edj.2018.79056 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| Reda Saber Moawad1; Lubna El-Gammal2; Hussein Ibrahim Saudi2; Mohammed Attia Saad3 | ||||
| 1Assistant Lecturer of Oral Medicine, Periodontology, Oral Diagnosis and Radiology Department, Faculty of Dentistry, Tanta University, Egypt | ||||
| 2Professor of Oral Medicine, Periodontology, Oral Diagnosis and Radiology Department, Faculty of Dentistry, Tanta University, Egypt | ||||
| 3Professor of Clinical Pathology Faculty of Medicine, Tanta University | ||||
| Abstract | ||||
| Introduction: In view of the importance and prevalence of Recurrent Aphthous Stomatitis (RAS) there is an urgent need for searching about an effective therapy that is less expensive, easy to use and readily available with no side effects. Low Level Laser Therapy (LLLT ) and Omega-3 were considered as possible treatment options of RAS. Aim of the work: The aim of the current study was to compare the usefulness of LLLT with or without omega-3 versus omega-3 alone in treatment of RAS and evaluate the immune-modulatory effect of systemically administered omega-3. Materials and method: 45 patients were suffering from RAS were randomly assigned into either GӀ: (LLL T), GӀӀ: (omega-3) and GӀӀӀ: (omega-3 plus LLL T). The comparison was assessed clinically via calculating: The reduction in ulcer surface area by using Visual Basic Program, the effectiveness indices (EI ) of pain improvement at day 1 and day five, average duration of ulcer episodes, and the number of new ulcer outbreaks at base line and then monthly for the following 6 months. Immunologically via: Measuring the amount of IL2, determination of CD4+CD25+ high T regulatory cells in blood samples at base line (BL), 3 and 6 months. Results: GӀ showed significant reduction in ulcer surface area and significant decrease in pain sensation, without significant change in all other parameters. GӀӀ showed no significant change in the degree of pain sensation in spite of reduction in ulcer surface area in addition to significant change in all other parameters. GӀӀӀ showed significant improvement in all clinical parameters which is compatible with the changes occurred in the immunologic parameters. At BL no significant deference was observed in between the three groups. For the follow up measurements: The reduction in ulcer surface area and (EI ) of pain improvement showed significant difference comparing GӀӀ with GӀ and GӀӀӀ in favor of the last mentioned two groups with no difference in between both of them, regarding the monthly clinical variables and immunologic parameters showed significant difference comparing GӀ with GӀӀ and GӀӀӀ in favor of the GӀӀ and GӀӀӀ with no difference in between both of them. Conclusions: Using LLLT with omega - 3 fatty acid in management of RAS gave the most favorable clinical and immunologic results. The used Visual Basic Program was effective in calculating the difference of ulcers surface areas and the digital data enabled fair statistical analysis. | ||||
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