Breast cancer molecular subtypes and the metastatic microenvironment: Review of literature | ||||
| Journal of Medical Histology | ||||
| Article 1, Volume 1, Issue 2, December 2017, Page 111-118 PDF (538.74 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/jmh.2017.7916 | ||||
 View on SCiNiTO | ||||
| Author | ||||
May Gohar 
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| Department of Medical Histology and Cell Biology, Faculty of Medicine, Cairo University, Cairo, Egypt | ||||
| Abstract | ||||
| Breast Cancer is a major public health concern worldwide. Breast cancer is the most common form of cancer and second leading cause of cancer death in women, with >90% of deaths resulting from metastasis. Clinically, human breast cancers are classified into distinct molecular subtypes (luminal A/B, Her2-positive, and triple-negative [TN]) which exhibit organ-specific patterns of metastasis. The lung is one of the most common sites of metastasis in patients with aggressive triple-negative (TN) disease, while less aggressive luminal A/B cancers most often metastasize to bone. Experimentally, it has been suggested that the presence of a primary tumor may serve to induce a “pre-metastatic niche” in the lung in order to make it more hospitable for metastasizing breast cancer cells. This review integrates how the cellular and molecular components of the metastatic niche evolve in the context of molecular subtype. Understanding the cancer-induced components of the metastatic niche will develop opportunities for improved clinical management and new therapeutic strategies. | ||||
| Keywords | ||||
| Molecular subtypes of breast cancer; organ metastasis; premetastatic niche | ||||
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