Hepatorenal Syndrome in Dogs with Experimental Extrahepatic Cholestasis
Bayoumi, Y., Metwally, E., El Nagar, E., Abdel Razik, W., El Seddawy, N., Gomaa, M. (2020). Hepatorenal Syndrome in Dogs with Experimental Extrahepatic Cholestasis. EKB Journal Management System, 48(1), 12-22. doi: 10.21608/zvjz.2019.15292.1068
Yasmin Bayoumi; Eman Metwally; El Abas El Nagar; Wafaa Abdel Razik; Nora El Seddawy; Mohamed Gomaa. "Hepatorenal Syndrome in Dogs with Experimental Extrahepatic Cholestasis". EKB Journal Management System, 48, 1, 2020, 12-22. doi: 10.21608/zvjz.2019.15292.1068
Bayoumi, Y., Metwally, E., El Nagar, E., Abdel Razik, W., El Seddawy, N., Gomaa, M. (2020). 'Hepatorenal Syndrome in Dogs with Experimental Extrahepatic Cholestasis', EKB Journal Management System, 48(1), pp. 12-22. doi: 10.21608/zvjz.2019.15292.1068
Bayoumi, Y., Metwally, E., El Nagar, E., Abdel Razik, W., El Seddawy, N., Gomaa, M. Hepatorenal Syndrome in Dogs with Experimental Extrahepatic Cholestasis. EKB Journal Management System, 2020; 48(1): 12-22. doi: 10.21608/zvjz.2019.15292.1068

Hepatorenal Syndrome in Dogs with Experimental Extrahepatic Cholestasis

Zagazig Veterinary Journal
Article 2, Volume 48, Issue 1, March 2020, Page 12-22  XML PDF (684.23 K)
Document Type: Original Article
DOI: 10.21608/zvjz.2019.15292.1068
View on SCiNiTO View on SCiNiTO
Authors
Yasmin Bayoumi email 1; Eman Metwally2; El Abas El Nagar1; Wafaa Abdel Razik1; Nora El Seddawy3; Mohamed Gomaa4
1Department of Animal Medicine (Internal Medicine), Faculty of Veterinary Medicine 44511, Zagazig University, Zagazig, Sharkia Governorate, Egypt
2Veterinary Hospital, Faculty of Veterinary Medicine 44511, Zagazig University, Zagazig, Sharkia Governorate, Egypt
3Department of Pathology, Faculty of Veterinary Medicine 44511, Zagazig University, Zagazig, Sharkia Governorate, Egypt
4Department of Surgery, Faculty of Veterinary Medicine 44511, Zagazig University, Zagazig, Sharkia Governorate, Egypt
Abstract
Hepatorenal syndrome (HRS) is a unique form of functional and potentially reversible renal failure secondary to liver diseases. It occurs typically in kidneys that are histologically normal. In this study, the hepatorenal syndrome was observed in a model of extrahepatic biliary stasis. Seven mature male mongrel dogs were subjected to complete surgical ligation of common bile duct at the duodenal region Clinical, ultrasonographic, , histopathological examinations along with biochemical analysis for liver enzymes and urinalysis were performed before and throughout the experimental periods. Clinical observations post-surgery revealed icteric mucosa, abdominal pain, weight loss, dehydration, orange-colored urine, bilirubinurea, and clay feces. Biochemical analysis showed an abrupt increase in the mean values of serum blood urea nitrogen and creatinine from the 3rd day till reaching the peak at the 2nd week post-surgery. A strong positive correlation was detected between BUN and creatinine, and serum total and direct bilirubin. Ultrasonographic findings of liver revealed a progressive dilatation of gallbladder and the common bile duct from the 3rd day post-ligation, with an increase in the echogenicty of the liver, whereas, the kidneys demonstrate normal renal parenchyma and dimensions. Histopathological examination of the kidney revealed hemorrhage, vacuolation, hyaline droplet were observed in renal tubules and edema and yellowish-brown granules were seen in the interstitial tissue, but the significant renal changes that refer to renal failure weren’t detected,. In conclusion, the dogs are considered a suitable model for studying hepatorenal syndrome and also there is an association between obstructive jaundice and renal failure.
Keywords
Hepatorenal syndrome; Obstructive jaundice; Dog; Biochemical analysis Pathological features
Statistics
Article View: 1,195
PDF Download: 464