The Serum C - reactive protein Level and Monocyte Count assessment among Adult Migraine Patients | ||||
| Zagazig University Medical Journal | ||||
| Article 428, Volume 27, Issue 3, May 2021, Page 511-515 PDF (503.94 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/zumj.2020.17420.1548 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
BAHAA ELSHEIKH  1; Elhady Abd-Elgawad2; Hanan Salah3; Walid Reda Ashour 2
| ||||
| 1Faculty of Medicine, Zagazig University, Department of Neurology, Sharkia Egypt | ||||
| 2Neurology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt | ||||
| 3neurology department, faculty of medicine, zagazig university, zagazig, Egypt | ||||
| Abstract | ||||
| Background: Migraine is a highly prevalent and frequently disabling condition. Its etiology is multifactorial, involving various genetic, environmental and inflammatory factors, hence, it is reasonable to assess the serum C-reactive protein level and monocyte count in migraine. Objective: Assessment of the serum C-reactive protein level and monocyte count among migraineurs. Subjects and Methods: This case-control prospective study was conducted on twenty-seven migraineurs attended the Neurology Outpatient Clinic of Zagazig University Hospital and diagnosed according to The International Classification of Headache Disorders, (3rd edition) and twenty-seven controls. All subjects underwent: Detailed medical, neurological and headache history, complete general and neurological examination and investigations: complete blood count (including monocyte count), liver and kidney function tests, lipid profile, blood glucose level, erythrocyte sedimentation rate, C-reactive protein level , electrocardiography and computed tomography brain and/or magnetic resonance imaging brain when indicated. Results: Migraine patients without preventive treatment had higher C-reactive protein level and monocytes count in comparison to others with treatment however; the difference was not a statistically significant. We can notice also that there is no correlation between monocyte count and C-reactive protein. In our study the monocyte count showed a statistically significant higher values in case group than control also, was a statistically significant area under the curve and cut off of monocyte regarding detection of cases >550, with sensitivity, specificity, +ve predictive, -ve predictive and accuracy were 81.5%, 59.3%, 66.7%, 76.1% and 70.3% respectively. Conclusion: Our findings suggest that the elevated C-reactive protein level and monocyte count are associated with migraine. | ||||
| Keywords | ||||
| C-reactive protein; Monocyte count; Migraine | ||||
|
Statistics Article View: 236 PDF Download: 356 |
||||
