THE EFFECT OF AMOXICILLIN ON THE SECRETORY STAGE OF AMELOGENESIS IN RATS
Mostafa, H., Shehata, F., Omar, S., Kawana, K. (2020). THE EFFECT OF AMOXICILLIN ON THE SECRETORY STAGE OF AMELOGENESIS IN RATS. EKB Journal Management System, 45(1), 34-38. doi: 10.21608/adjalexu.2020.79929
Hossam M. Mostafa; Fathy I. Shehata; Samia O. Omar; Khadiga Y. Kawana. "THE EFFECT OF AMOXICILLIN ON THE SECRETORY STAGE OF AMELOGENESIS IN RATS". EKB Journal Management System, 45, 1, 2020, 34-38. doi: 10.21608/adjalexu.2020.79929
Mostafa, H., Shehata, F., Omar, S., Kawana, K. (2020). 'THE EFFECT OF AMOXICILLIN ON THE SECRETORY STAGE OF AMELOGENESIS IN RATS', EKB Journal Management System, 45(1), pp. 34-38. doi: 10.21608/adjalexu.2020.79929
Mostafa, H., Shehata, F., Omar, S., Kawana, K. THE EFFECT OF AMOXICILLIN ON THE SECRETORY STAGE OF AMELOGENESIS IN RATS. EKB Journal Management System, 2020; 45(1): 34-38. doi: 10.21608/adjalexu.2020.79929

THE EFFECT OF AMOXICILLIN ON THE SECRETORY STAGE OF AMELOGENESIS IN RATS

Alexandria Dental Journal
Article 6, Volume 45, Issue 1, April 2020, Page 34-38  XML PDF (289.33 K)
Document Type: Original Article
DOI: 10.21608/adjalexu.2020.79929
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Authors
Hossam M. Mostafa email 1; Fathy I. Shehata2; Samia O. Omar2; Khadiga Y. Kawana2
1Master of science degree in Oral Biology 2015, Alexandria University
2Professor of Oral Biology, Faculty of Dentistry, Alexandria University.
Abstract
Introduction: Molar–incisor hypomineralization is a developmental enamel defect affecting first permanent molars and incisors. The intake of antibiotics during pregnancy and early childhood has been associated with molar incisor hypomineralization.
Objectives: Was to determine the effect of amoxicillin on the secretory a stage of amelogenesis histologically and histomorphometrically.
Materials and methods: Fourteen pregnant rats were randomly assigned to two groups that received physiological solution (control group), 250 mg/kg/day amoxicillin (study group). Directly after birth, fourteen pups representing each group received the same treatment with dose equivalent to their body weight then they were euthanized at day 7 birth. The ameloblasts of developing molars were examined histologically and histomorphometrically.
Results:In day 7 after birth, the ameloblasts in control group revealed normal features of amelogenesis while in study group, numerous vacuolar like structures were seen in between secretory ameloblasts.
Conclusions: Amoxicillin disrupts the normal structure of enamel and impairs the secretion of enamel matrix
Keywords
Ameloblast; amoxicillin; secretory; amelogenesis
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