Determination of Flucloxacillin-sodium in Binary Mixture with Ampicillin-trihydrate Using Univariate and Multivariate Spectrophotometric Methods: A Comparative Study | ||||
| Journal of Advanced Pharmacy Research | ||||
| Article 4, Volume 2, Issue 3, July 2018, Page 180-190 PDF (914.14 K) | ||||
| Document Type: Research Article | ||||
| DOI: 10.21608/aprh.2018.2362.1047 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Khalid Abdel-Salam Attia1; Omar Abdel-Aziz2; Nancy Nasef2; Ghada Mohamed  1
| ||||
| 1Department of Pharmaceutical Analytical Chemistry Faculty of Pharmacy, Al-Azhar University, Nasr City, Cairo, Egypt. | ||||
| 2Pharmaceutical Analytical Chemistry, Faculty of pharmacy, Ain shams Univeristy | ||||
| Abstract | ||||
| Objectives: The aim of this study was to develop four simple and accurate spectrophotometric methods for determination of flucloxacillin-sodium in binary mixture with ampicillin-trihydrate without separation. Methods: One of them was a univariate constant center method and the other three methods were multivariate chemometric methods named; Savitsky-Golay filters, continuous wavelet transform of ratio spectra and wavelet transform of first derivative of the ratio spectra. Results: The proposed methods adopted for selective determination of flucloxacillin-sodium and obey Beer’s law in the range (2-20 µg mL-1). Conclusion: The proposed methods were simple, rapid, economic, accurate and precise; they were successfully applied for the determination of flucloxacillin-sodium in pure form and in pharmaceutical preparations. | ||||
| Keywords | ||||
| Constant center; Continuous wavelet transform; Flucloxacillin-sodium; Multivariate chemometric; Savitsky-Golay filters | ||||
|
Statistics Article View: 340 PDF Download: 792 |
||||
