Novel p-nitrophenyl Maleanilic Acid and Its Organometallic Chelates of Cr, Mo and W Carbonyls Structure Evaluation Using Different Techniques and Chromium Chelate Cytotoxicity | ||||
| Egyptian Journal of Chemistry | ||||
| Article 15, Volume 63, Issue 11, November 2020, Page 4327-4340 PDF (1.3 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejchem.2020.24342.2446 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
mohamed A. Zayed   1; Khloud.R. Oraby2; Fatma.S.M. Hassan2
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| 1Department of chemistry, Faculty of Science, Cairo University (D.Sc. Anal.Chem.) | ||||
| 2Chemistry Department, Science Faculty, Aswan University, 81528 Egypt | ||||
| Abstract | ||||
| Novel p-nitrophenyl maleanilic acid bidentate free ligand (PNMA) was synthesized eco-friendly by solvent free reaction between 4-nitroaniline and maleic anhydride. Some novel mixed ligand organometallic chelates of formulae [M(CO)4L] (M = Cr , Mo , or W and L = PNMA) were carefully prepared under nitrogen inert gas atmosphere by condensation between ligand PNMA and hexacarbonyl of metal cations Cr , Mo , or W in 1:1 molar ratio. The chemical structures of PNMA free ligand and its novel chelates had been evaluated by elemental analyses, FTIR spectroscopy, 1H-NMR, mass spectroscopy, and thermal analyses (TGA and DTG). The chemical structures of both PNMA free ligand and its chelates were investigated also by XRD technique. The free ligand and its chromium chelate had been evaluated for their anticancer activities against MCF‐7 cells (breast cancer cell line), HCT116 cells (colon cancer cell line) and HepG2 cells (human liver cancer cell line). | ||||
| Keywords | ||||
| KEYWORDS: P-nitrophenyl maleanilic acid; organometallic carbonyl chelates; antitumor activity; spectroscopic analysis; XRD and thermal analysis | ||||
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