Prevalence of multidrug resistance in the Egyptian methicillin-resistant Staphylococcus aureus isolates

Ibrahim, Eman S.H.; El-Baghdady, Khaled; Abd El-All, Said M.; Warda, Mohamed A.A.; Prince, Abdelbary M.; Ibrahim, Mohamed

doi:10.21608/ajbs.2020.80481

	Prevalence of multidrug resistance in the Egyptian methicillin-resistant Staphylococcus aureus isolates
African Journal of Biological Sciences
Article 5, Volume 16, Issue 1, 2020, Page 43-52 PDF (512.6 K)
Document Type: Original Article
DOI: 10.21608/ajbs.2020.80481
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Authors
Eman S.H. Ibrahim¹; Khaled El-Baghdady ²; Said M. Abd El-All¹; Mohamed A.A. Warda³; Abdelbary M. Prince³; Mohamed Ibrahim⁴
¹National Organization for Drug Control and Research, Giza, Egypt
²Department of Microbiology, Faculty Science, Ain Shams Univ., Cairo, Egyp
³Department of Biochemistry, Faculty of Veterinary Medicine, Cairo Univ., Giza, Egypt
⁴Department of Microbiology, Faculty Science, Ain Shams Univ., Cairo, Egypt
Abstract
Methicillin-resistant Staphylococcus aureus (MRSA) is one of the major health hazards and became of greater public health concern. This work aimed to shed substantial light on prevalence of MRSA in different clinical isolates and their resistance to different antibiotics. Among 258 Staphylococcus aureus isolates recovered from different clinical sources (urine, pus, throat swab, blood, seminal fluid, prostatic fluid, sputum swab, ascetic fluid, skin swab, nipple discharge and urinary catheter). 70 isolates were identified as MRSA. The highest percentage of MRSA was recorded from pus samples (57.1%) followed by urine (30%). Antimicrobial susceptibility test using 14 antibiotics showed that all MRSA were resistant to amoxicillin and cefuroxime, while only 50% were sensitive to vancomycin. High minimum inhibitory concentration of oxacillin (256 µg/ml) was detected in 12.9% of MRSA isolates.
Keywords
Staphylococcus aureus; MRSA; Oxacillin; ORSAB; Clinical


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