Management of chronic hepatitis B in special populations | ||||
Medical Journal of Viral Hepatitis | ||||
Article 3, Volume 4.2, Issue 2, March 2020, Page 63-68 PDF (168.51 K) | ||||
Document Type: Review articles | ||||
DOI: 10.21608/mjvh.2020.80654 | ||||
View on SCiNiTO | ||||
Authors | ||||
Elbadrawy Elsaid1; Zaher Tarik1; Mousa Eman2; Elshenaway Mostafa3; Alhawarey Ahmed3; Abdel-Aziz Mohamed3; Elgamal Hoda3 | ||||
1Tropical Medicine dept., Zagazig Univ., Zagazig, Egypt | ||||
2Faculty of Dentistry, Mansoura Univ., Egypt | ||||
3Tropical Medicine dept., Mansoura Univ, Mansoura, Egypt | ||||
Abstract | ||||
Hepatitis B infection is an international healthcare problem, particularly in developing areas. The hepatitis B virus (HBV) is frequently transmitted via body fluids such as blood, semen, and vaginal secretions. The majority of adults infected with the virus recover, however 5%-10% are not capable to clear the virus and become chronically infected. The principal treatment goals for patients with hepatitis B infection are to prevent progression of the liver disease to cirrhosis or hepatocellular carcinoma. The effective nucleos(t)ide analogs (NAs) against hepatitis B virus (HBV) has improved the outcome of patients with chronic hepatitis B (CHB). Special populations infected with chronic HBV include those with decompensated cirrhosis, organ transplantation, pregnancy, extrahepatic manifestations, immunosuppressive-chemotherapy, co-infections (HIV-HCV- HDV), renal failure, hepatitis B virus infection in children/adolescents and dental practice. These populations vary in their natural history and risk of liver-related complications, the indications for anti-HBV treatment in addition to the recommendations concerning the HBV drugs used, time of therapy and expected endpoints. The aim of this review is to summarize the information on the relevance and treatment of HBV infection in such special populations. | ||||
Keywords | ||||
Hepatitis B virus; Cirrhosis; Pregnancy; HBV-HCV coinfection; HBV Reactivation; Nucleos(t)ide analogues and dental practice | ||||
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