Expression of Nerve Growth Factor and Tyrosine Kinase A in Laryngeal Squamous Cell Carcinoma: A Novel Study | ||||
| The Medical Journal of Cairo University | ||||
| Article 80, Volume 87, December, December 2019, Page 4679-4683 PDF (670.3 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/mjcu.2019.80830 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| MOSTAFA A. ABOU SARIE, M.D.; HALA M. EL-HANBULI, M.D.; LUBNA O. ABDEL-SALAM, M.D. | ||||
| The Department of Pathology, Faculty of Medicine, Fayoum* and Cairo** Universities, Egypt | ||||
| Abstract | ||||
| Abstract Background: Laryngeal Squamous Cell Carcinoma (LS-CC) is a common cancer worldwide so knowing the biological markers related to this tumor aggressiveness can help improv-ing the patient's management. A recent attention was payed towards Nerve Growth Factor (NGF) and its receptors in tumorigenesis. Aim of Study: This work aimed at studying for the first time the immunohistochemical expression of NGF and its TrkA receptor in LSCC and determine the possibility of finding a relationship between their expression and the different clinico-pathological data of the patients especially the clinical stage of the disease. Material and Methods: Using the immunohistochemical staining, the expression of NGF and TrkA was evaluated in 60 LSCC tissues. Results: The result showed that the expression of both NGF and TrkA was significantly related to the nodal status, the tumor and the clinical stages of the patients (p<0.001). Conclusion: The increased expression of both markers in advanced clinical stage of the disease suggested considering them as potential markers not only as prognostic factors, but also as a therapeutic target in LSCC. | ||||
| Keywords | ||||
| Laryngeal Squamous Cell Carcinoma (LSCC) – Nerve Growth Factor (NGF) – Tropomyosin-related kinase A (TrkA) | ||||
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