HEMOCHROMATOSIS HFE GENE POLYMORPHISM AND DEVELOPMENT OF PREDIABETES AND DIABETES MELLITUS IN B THALASSEMIC PATIENTS
ahmed, S., Abd El Hamid, I., mohamed, M., Abdel-Fattah, N. (2022). HEMOCHROMATOSIS HFE GENE POLYMORPHISM AND DEVELOPMENT OF PREDIABETES AND DIABETES MELLITUS IN B THALASSEMIC PATIENTS. EKB Journal Management System, 28(3), 454-462. doi: 10.21608/zumj.2020.17226.1534
sammer ahmed; Ihab Abd El Hamid; marwa mohamed; Nermin Raafat Abdel-Fattah. "HEMOCHROMATOSIS HFE GENE POLYMORPHISM AND DEVELOPMENT OF PREDIABETES AND DIABETES MELLITUS IN B THALASSEMIC PATIENTS". EKB Journal Management System, 28, 3, 2022, 454-462. doi: 10.21608/zumj.2020.17226.1534
ahmed, S., Abd El Hamid, I., mohamed, M., Abdel-Fattah, N. (2022). 'HEMOCHROMATOSIS HFE GENE POLYMORPHISM AND DEVELOPMENT OF PREDIABETES AND DIABETES MELLITUS IN B THALASSEMIC PATIENTS', EKB Journal Management System, 28(3), pp. 454-462. doi: 10.21608/zumj.2020.17226.1534
ahmed, S., Abd El Hamid, I., mohamed, M., Abdel-Fattah, N. HEMOCHROMATOSIS HFE GENE POLYMORPHISM AND DEVELOPMENT OF PREDIABETES AND DIABETES MELLITUS IN B THALASSEMIC PATIENTS. EKB Journal Management System, 2022; 28(3): 454-462. doi: 10.21608/zumj.2020.17226.1534

HEMOCHROMATOSIS HFE GENE POLYMORPHISM AND DEVELOPMENT OF PREDIABETES AND DIABETES MELLITUS IN B THALASSEMIC PATIENTS

Zagazig University Medical Journal
Article 9, Volume 28, Issue 3, May 2022, Page 454-462  XML PDF (364.63 K)
Document Type: Original Article
DOI: 10.21608/zumj.2020.17226.1534
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Authors
sammer ahmed email 1; Ihab Abd El Hamid2; marwa mohamedorcid 3; Nermin Raafat Abdel-Fattah4
1department of pediatrics.faculty of medicine .zagazig university
2Department of Pediatrics, Faculty of Medicine –Zagazig University, Egypt
3pediatric department, faculity of medicine, zagazig university
4Medical Biochemistry, Faculty of Medicine, Zagazig University, Egypt
Abstract
Abstract
Background:.β-thalassemias constitute a major health problem in mediterranean countries. Impaired glucose tolerance and diabetes mellitus are observed complications in patients with thalassemia .However, the mechanisms leading to diabetes are still poorly understood. The H63D polymorphism,is the second variant of hemochromatosis HFE genethat cause hemochromatosis
Objective: to asses the frequency of H63D gene polymorphism and its relationship to development of prediabetes and diabetes mellitus in β -thalassemia patients
Method: A case control study was carried on 50 β-thalassemia patients who were registered in and followed up at hematology outpatient clinic; Pediatric department, Zagazig University with age range from 6 to 18years and 50 age and sex matched healthy control through a period of 6 months.
Results : our study showed that 32% of patients had normal glycemic state, 52% had prediabetes and 16% were diabetic P
Keywords
thalassemia; diabetes; HFE gene mutation
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