Effect of (+) and (-) hydroxycitric acid sterio-isomers present in natural products in counteracting insulin resistance
farouk, H., Saad, M., Mahmoud, S., El-Yamany, M., Sharaf, O., Ahmed, R., El-Denshary, E. (2020). Effect of (+) and (-) hydroxycitric acid sterio-isomers present in natural products in counteracting insulin resistance. EKB Journal Management System, 63(11), 4341-4354. doi: 10.21608/ejchem.2020.25054.2493
hadir farouk; Muhammed A. Saad; Sawsan S. Mahmoud; Mohammed F. El-Yamany; Ola A. Sharaf; Rania F. Ahmed; Ezz E. El-Denshary. "Effect of (+) and (-) hydroxycitric acid sterio-isomers present in natural products in counteracting insulin resistance". EKB Journal Management System, 63, 11, 2020, 4341-4354. doi: 10.21608/ejchem.2020.25054.2493
farouk, H., Saad, M., Mahmoud, S., El-Yamany, M., Sharaf, O., Ahmed, R., El-Denshary, E. (2020). 'Effect of (+) and (-) hydroxycitric acid sterio-isomers present in natural products in counteracting insulin resistance', EKB Journal Management System, 63(11), pp. 4341-4354. doi: 10.21608/ejchem.2020.25054.2493
farouk, H., Saad, M., Mahmoud, S., El-Yamany, M., Sharaf, O., Ahmed, R., El-Denshary, E. Effect of (+) and (-) hydroxycitric acid sterio-isomers present in natural products in counteracting insulin resistance. EKB Journal Management System, 2020; 63(11): 4341-4354. doi: 10.21608/ejchem.2020.25054.2493

Effect of (+) and (-) hydroxycitric acid sterio-isomers present in natural products in counteracting insulin resistance

Egyptian Journal of Chemistry
Article 16, Volume 63, Issue 11, November 2020, Page 4341-4354  XML PDF (584.12 K)
Document Type: Original Article
DOI: 10.21608/ejchem.2020.25054.2493
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Authors
hadir farouk email 1; Muhammed A. Saad2; Sawsan S. Mahmoudorcid 3; Mohammed F. El-Yamany4; Ola A. Sharaf5; Rania F. Ahmed6; Ezz E. El-Denshary4
1Pharmacology department National Research Centre
2Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University. School of Pharmacy, New Giza University
3Pharmacology Department, Medical Research Division, National Research Centre, Dokki, Giza, Egypt,
4Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University.
5Department of Pharmacology, National Research Centre
6Researcher-Pharmacology Department National Research Centre
Abstract
Metabolic syndrome is a cluster of cardiovascular and metabolic risk factors that include impaired glucose metabolism and obesity. The use of nutraceuticals is an ideal choice for controlling this disorder. The aim of the present study is to investigate the effect (-) hydroxycitric acid present in garcinia fruit rind and (+) hydroxycitric acid present in hibiscus calyx on metabolic syndrome and compare it to that of metformin. Metabolic syndrome was induced in rats by ingestion of high fat high fructose (HFHF) diet for 90 days. Metformin (500 mg/Kg animal b.wt.), garcinia (1000 mg/Kg animal b.wt.) and hibiscus (250 mg/Kg animal b.wt) were orally administered throughout the last 30 days of the HFHF diet regimen. Both garcinia and hibiscus were effective in reducing serum blood glucose and insulin levels. The effect of garcinia on blood glucose was comparable to that of metformin, while the effect of hibiscus on insulin and HOMA-IR was comparable to that of metformin. Both were able to reduce serum leptin level. All treated groups showed a significant decrease in total cholesterol level. Only hibiscus was able to normalize liver function while garcinia failed to reduce the elevated liver function. As a conclusion we would recommend the use of hibiscus over garcinia to overcome the adverse effects of metabolic syndrome.
Keywords
Metabolic syndrome; Hydroxycitric acid; Metformin; Garcinia; Hibiscus; Liver functions
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