Synthesis and kinetic study for the interconversion process of some 2'–hydroxychalcones to their corresponding flavanones | ||||
| Egyptian Journal of Chemistry | ||||
| Article 19, Volume 63, Issue 11, November 2020, Page 4379-4386 PDF (919.95 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejchem.2020.22974.2363 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Zainab W Majed   1; Said Abdelqader Said 2; Omar Adil Shareef 3
| ||||
| 1Department of New and Renewable Energies ,College of Scienc | ||||
| 2Department of Chemistry ,University of Mosul, College of Science,Mosul-Iraq | ||||
| 3Department of Chemistry, University of Mosul, College of Science, Mosul-Iraq | ||||
| Abstract | ||||
| In this work, five substituted 2'-Hydroxychalcones were prepared using Claisen - Schmidt condensation which were used then as a synthone for substituted flavanones via base catalyzed isomerization. The latter process has been studied kinetically in order to determine the rate constant. These experiments were performed using HPLC technique in (8:2) (CH3CN:CH3OH) medium at different temperatures (298 K - 318 K). The obtained results were interpreted by a four-step mechanism which considered the existence of phenoxide ion as the key intermediate. The main reaction was achieved as a pseudo first order reaction in which the rate of the studied compounds followed the sequence 1>2>3>4>5, and the activation energy had the same sequence for these compounds. The reaction rate was affected by the electronic behavior of the different substituents at ring B since they played an important role in the stability of the intermediate that led to the final product. | ||||
| Keywords | ||||
| 2-Hydroxy chalcones; flavanones; phenoxide ion; isomerization | ||||
|
Statistics Article View: 548 PDF Download: 522 |
||||
