Serum Vitamin D levels in Rheumatoid arthritis and Relationship with disease activity
Elamir, A., Ibrahim, T., Fouad, N., Masoud, M. (2022). Serum Vitamin D levels in Rheumatoid arthritis and Relationship with disease activity. EKB Journal Management System, 38(2), 175-184. doi: 10.21608/besps.2018.8206
Azza Elamir; Tarek Ibrahim; Nermeen A. Fouad; Mohamed Masoud. "Serum Vitamin D levels in Rheumatoid arthritis and Relationship with disease activity". EKB Journal Management System, 38, 2, 2022, 175-184. doi: 10.21608/besps.2018.8206
Elamir, A., Ibrahim, T., Fouad, N., Masoud, M. (2022). 'Serum Vitamin D levels in Rheumatoid arthritis and Relationship with disease activity', EKB Journal Management System, 38(2), pp. 175-184. doi: 10.21608/besps.2018.8206
Elamir, A., Ibrahim, T., Fouad, N., Masoud, M. Serum Vitamin D levels in Rheumatoid arthritis and Relationship with disease activity. EKB Journal Management System, 2022; 38(2): 175-184. doi: 10.21608/besps.2018.8206

Serum Vitamin D levels in Rheumatoid arthritis and Relationship with disease activity

Bulletin of Egyptian Society for Physiological Sciences
Article 7, Volume 38, Issue 2, April 2022, Page 175-184  XML PDF (850.06 K)
Document Type: Original Article
DOI: 10.21608/besps.2018.8206
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Authors
Azza Elamir email orcid 1; Tarek Ibrahim2; Nermeen A. Fouad3; Mohamed Masoud4
1Department of Medical Biochemistry, Faculty of Medicine, Fayoum University, Fayoum, Egypt.
2Department of Internal Medicine, Faculty of Medicine, Fayoum University, Fayoum, Egypt.
3Department of Rheumatology and Rehabilitation, Faculty of Medicine, Fayoum University, Fayoum, Egypt.
4Department of public health, Faculty of Medicine, Fayoum University, Fayoum, Egypt.
Abstract
Aim: This study was designed to measure the serum level of vitamin D in patients with rheumatoid arthritis, and to correlate it with disease activity. Method: 41 patients of Rheumatoid arthritis fulfilling the ACR/EULAR classification criteria for RA and 20 healthy controls were included in the study. Disease activity was evaluated by DAS-28 score. 25 (OH) vitamin D and CRP levels were measured using ELISA Kit. Results: 9 patients had high disease activity (DAS-28 score >5.1), 25 patients had moderate disease activity (DAS 28 score 3.2-5.1, group B) and 7 patients had low disease activity (DAS-28 score ≤ 3.2). Mean serum level of vitamin D of RA patients was significantly low compared to healthy controls (P<0.0001). There was statistically significant negative correlation between vitamin D and DAS-28 (r = -0.388, P = 0.031). Conclusion: Serum level of vitamin D of RA patients was significantly low compared to healthy controls and vitamin D had statistically significant negative correlation with disease activity in RA.
Keywords
Rheumatoid Arthritis; Vitamin D
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