Histological changes of human placenta in early intrauterine growth restriction with and without preeclampsia
Askar, E., Selim, S., Sibai, H. (2019). Histological changes of human placenta in early intrauterine growth restriction with and without preeclampsia. EKB Journal Management System, 3(1), 65-76. doi: 10.21608/jmh.2019.12648.1056
Eman Askar; Sally Selim; Hoda Sibai. "Histological changes of human placenta in early intrauterine growth restriction with and without preeclampsia". EKB Journal Management System, 3, 1, 2019, 65-76. doi: 10.21608/jmh.2019.12648.1056
Askar, E., Selim, S., Sibai, H. (2019). 'Histological changes of human placenta in early intrauterine growth restriction with and without preeclampsia', EKB Journal Management System, 3(1), pp. 65-76. doi: 10.21608/jmh.2019.12648.1056
Askar, E., Selim, S., Sibai, H. Histological changes of human placenta in early intrauterine growth restriction with and without preeclampsia. EKB Journal Management System, 2019; 3(1): 65-76. doi: 10.21608/jmh.2019.12648.1056

Histological changes of human placenta in early intrauterine growth restriction with and without preeclampsia

Journal of Medical Histology
Article 5, Volume 3, Issue 1, June 2019, Page 65-76  XML PDF (2.53 MB)
Document Type: Original Article
DOI: 10.21608/jmh.2019.12648.1056
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Authors
Eman Askar1; Sally Selim* 1; Hoda Sibai2
1Department of Histology and Cell Biology, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
2Department of Obstetrics and Gynecology, Faculty of Medicine, Zagazig University, Zagazig, Egypt
Abstract
Background: Intra uterine growth restriction (IUGR) is a common pregnancy complication, pre-eclamsia (PE) is an important
cause of this complication and is responsible for maternal and fetal morbidity and mortality. Idiopathic intrauterine growth
restriction without obvious causes is not uncommon.
Objective: The aim of this study is to examine the placental histology in both conditions trying to find specific criteria for each
disorder.
Materials and Methods: This study was conducted on three groups; group I was the control group, group II was preeclampsia
induced IUGR (PE-IUGR) group and group III was idiopathic IUGR (I-IUGR). Each group contained 15 placentas. Placental
specimens from each group were analyzed histopathologically and immunohistochemically.
Results: we found that PE-IUGR and I-IUGR cases in this study share common histological changes suggesting a similar
pathogenesis. Maternal mal-perfusion lesions predominated in PE-IUGR. Findings consistent with fetal vascular malperfusion
were higher in I-IUGR. Hofbauer cells (HBC) were increased in both PE-IUGR and I-IUGR.
Conclusion: abnormal utero-placental blood vessels and utero-placental insufficiency and the resulting histological changes in
the chorionic villi, and chronic inflammatory lesions may be the primary disease processes related to the placental pathology
of PE-IUGR and I-IUGR.
Keywords
Decidual vasculopathy; fetal vascular obstruction intrauterine growth restriction; placenta; preeclampsia
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