FORMALDEHYDE HEALTH HAZARDS AND ITS PRECARCINOGENIC EFFECTS
HH, Z., BM, L., DA, S., OE, M., RM, S. (2016). FORMALDEHYDE HEALTH HAZARDS AND ITS PRECARCINOGENIC EFFECTS. EKB Journal Management System, 40(1), 95-108. doi: 10.21608/ejom.2016.834
Zayet HH; Lotfy BM; Sabry DA; Mohamed OE; Said RM. "FORMALDEHYDE HEALTH HAZARDS AND ITS PRECARCINOGENIC EFFECTS". EKB Journal Management System, 40, 1, 2016, 95-108. doi: 10.21608/ejom.2016.834
HH, Z., BM, L., DA, S., OE, M., RM, S. (2016). 'FORMALDEHYDE HEALTH HAZARDS AND ITS PRECARCINOGENIC EFFECTS', EKB Journal Management System, 40(1), pp. 95-108. doi: 10.21608/ejom.2016.834
HH, Z., BM, L., DA, S., OE, M., RM, S. FORMALDEHYDE HEALTH HAZARDS AND ITS PRECARCINOGENIC EFFECTS. EKB Journal Management System, 2016; 40(1): 95-108. doi: 10.21608/ejom.2016.834

FORMALDEHYDE HEALTH HAZARDS AND ITS PRECARCINOGENIC EFFECTS

Egyptian Journal of Occupational Medicine
Article 7, Volume 40, Issue 1, January 2016, Page 95-108  XML PDF (188.68 K)
Document Type: Study paper
DOI: 10.21608/ejom.2016.834
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Authors
Zayet HH1; Lotfy BM1; Sabry DA2; Mohamed OE3; Said RM1
1Department of Occupational and Environmental Medicine
2Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Cairo University
3Human Cytogenetics, National Research Center
Abstract
Introduction: Formaldehyde (FA) is a high-production-volume chemical with a wide array of uses. Recently, it was re-evaluated for its carcinogenic effects and reclassified as humans carcinogen (Group 1) based on sufficient evidence in human and experimental animal studies. Aim of the work: to evaluate the pre-carcinogenic effects of formaldehyde among medical personnel in The Histopathology Laboratory. Materials and Methods: The study was conducted in histopathology laboratory including 30 workers occupationally exposed to formaldehyde and 29 persons matching with the exposed group for age, sex and socioeconomic status with no history of occupational exposure to formaldehyde. A questionnaire was done including inquiries about age, sex, occupational history and special habits. All participants were subjected to the following laboratory investigations: measuring DNA protein crosslink (DPC) and protein 53 (p53) both mutant and wild type. Results: This study shows statistically significant increase in symptoms and signs of respiratory and eye and skin irritation with significant increase of DPC and p53 wild and mutant types as pre carcinogenic effects of formaldehyde. Conclusion: The studied group in the histopathology laboratory was exposed to formaldehyde level above the exposure limits recommended by NIOSH, ACGIH and OSHA with adverse health effects in the form of increase in DPC and p53 (wild and mutant types) which are considered to play an important role in the carcinogenesis of FA.
 
Keywords
Formaldehyde; Environmental monitoring; DNA protein crosslink (DPC); Protein 53(p53
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