EVALUATION OF ACUTE TOXICITY AND TERATOGENIC EFFECTS OF SOME PLANT GROWTH REGULATORS ON ALBINO RAT EMBRYO | ||||
| Journal of Plant Protection and Pathology | ||||
| Article 3, Volume 3, Issue 9, September 2012, Page 905-919 PDF (469.18 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/jppp.2012.84343 | ||||
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| Authors | ||||
| H. I. El-sayyad1; M. H. Abo Egla2; M. M. Mortada3; Manal M. Ramadan3; M. E. Elbeeh3 | ||||
| 1Fac. Sci., Mans. Univ | ||||
| 2Plant Protection Res. Inst.,Ministry Of Agric., Egypt | ||||
| 3Fac. Sci., Mans. Univ., | ||||
| Abstract | ||||
| Gibberellic acid(GA3) and Indole acetic acid (IAA) is an endogenous plant growth regulator used world wide in agriculture ;however, little is known about its biochemical and physiological effects on mammals. This study investigated possible toxic and teratogenic effects of GA3 and IAA on the embryo of albino rats. Female Wistar rats were given daily 200 ppm / 0.2 ml saline from either GA3 or IAA orally from the 1st day of pregnancy until the 14th, 16th, or after delivery. Toxicity was demonstrated by a significant increase in malondialdehyde level and a decrease in the antioxidant enzyme activities of catalase, superoxide dismutase, and glutathione peroxidase in the brain, spinal cord, eye, and liver of pups. A significant decline of glutathione content was also observed. The biochemical parameters were correlated histologically with an abnormal development of the external morphology and formation of the skeleton of either GA3 or IAA-treated pups. | ||||
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