Clinical presentation and surgical management of Glomatosis Cerebri | ||||
| International Journal of Sustainable Development and Science | ||||
| Article 7, Volume 1, Issue 2, June 2018, Page 1-14 PDF (610.59 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ijsrsd.2018.8536 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Mohamed Youssef ALQazaz1; Mohamed Mohamed Elsamahy  2
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| 1Assistant professor of Neurosurgery, Faculty of Medicine, Suez Canal University, Ismailia, Egypt. | ||||
| 2Suez Canal University,Ismailia,Department of Neurology,Egypt | ||||
| Abstract | ||||
| Background: Glomatosis Cerebri (GC) is a diffuse brain neoplasm whose prognosis is unfavourable. Aim: to investigate the clinical presentation, radiological and pathological features, and outcomes after treatment of GC. Patients and Methods: We collected data from fifteen patients with GC treated at Suez Canal University, during a ten-year period. The diagnosis was based on magnetic resonance imaging (MRI) findings and tissue biopsy of all patients except one patient who received blind radiotherapy. Results: Seven patients were male (47%), and their median age at presentation was 43 years (range, 6 75 years). Statistical analysis demonstrated median survival as follows: blind radiotherapy, 1 month (n = 1); biopsy then radiotherapy, 19 months (8 32 months; n = 9); subtotal excision then radiotherapy, 5 months (1-7 months; n=5). Karnofsky Performance Scale scores of 70 and tumor grade were both significantly related to length of survival. Conclusion: Our findings suggest that biopsies are useful not only for diagnosis but also for prediction of the length of survival. | ||||
| Keywords | ||||
| GC; Outcome; Biopsy; Radiotherapy | ||||
| References | ||||
|
1-Nevin S: GC. Brain. 61:170191, 1938.
2-Broniscer, A, Omar C, Scott H, Tong L, Stanley P, et al.: "GC in children shares molecular characteristics with other pediatric gliomas." Acta neuropathologica 131 [2]: 299-307, 2016.
3-Kleihues P and Cavenee WK: Pathology and Genetics of Tumors of the Nervous System.Lyon, IARC Press, 2000.
4-Artigas J, Cervos-Navarro J, Iglesias JR, Ebhardt G: GC: clinical and histological findings. Clin Neuropathol; 4:135-148, 1985
5-Del Carpio-O'Donovan R, Korah I, Salazar A, Melancon D: GC. Radiology. 198:831835, 1996
6-Couch JR, Weiss SA: GC: Neurology. 24:504511, 1974.
7-Elshaikh MA, Stevens GH, Peereboom DM, Cohen BH, Prayson RA, Lee SY, et al: GC:. Cancer. 95:20272031, 2002.
8-Ross IB, Robitaille Y, Villemure JG, Tampieri D: Diagnosis and management of GC: Surg Neurol. 36:431440, 1991.
9-Horst E, Micke O, Romppainen ML, Pyhtinen J, Paulus W, Schafer U, et al: Radiation therapy approach in GC:. Acta Oncol. 39:747751, 2000.
10-Jennings MT, Frenchman M, Shehab T, Johnson MD, Creasy J, LaPorte K, Dettbarn WD: GC presenting as intractable epilepsy during early childhood. J Child Neurol. 10:3745, 1995.
11-Kim DG, Yang HJ, Park IA, Chi JG, Jung HW, Han DH, Choi KS, Cho BK: GC:. Acta Neurochir [Wien]. 140:755762, 1998.
12-Koslow SA, Claassen D, Hirsch WL, Jungreis CA: GC: a case report with autopsy correlation. Neuroradiol; 34:331-333; 1992.
13-Ponce P, Alvarez-Santullano MV, Otermin E, Santana MA, Garcia Ludena MV: GC:. Eur J Radiol. 28:226229, 1998.
14-Mineura K, Sasjima T, Kowada M et al: Innovative approach in the diagnosis of GC using carbon-11-L-methionine position emission tomography, J Nuc Med; 32:726-728; 1991.
15-Shin YM, Chang KH, Han MH, Myung NH, Chi JG, Cha SH et al: GC:. AJR Am J Roentgenol. 161:859862, 1993.
16-Freund M, Hahnel S, Sommer C, Martmann M, Kiessling M, Tronnier V, Sartor K: CT and MRI findings in GC:. Eur Radiol. 11:309316, 2001.
17-George, Emilie, Allison S, Scott C, Jeffrey P.: "Pediatric GC A Review of 15 Years." Journal of child neurology 31 [3]: 378-387, 2016.
18-Felsberg GJ, Silver SA, Brown MT, Tien RD: Radiologic-pathologic correlation:AJNR Am J Neuroradiol. 15:17451753, 1994.
19-Scheinker M and Evans JP: Diffuse cerebral glioblastosis. J Neuropathol Exp Neurol; 2:178-89; 1943.
20-Cozad SC, Townsend P, Morantz RA, Jenny AB, Kepes JJ, Smalley SR: GC:. Cancer. 78:17891793, 1996.
21-Kandler RH, Smith CM, Broome JC, Davies-Jones GA: GC:Br J Neurosurg. 5:187193, 1991.
22-Curran WJ, Scott CB, Horton J, Nelson JS, Weinstein AS, Fischbach AJ, Chang CH, et al: Recursive partitioning analysis of prognostic factors in three Radiation Therapy Oncology Group malignant glioma trials. J Nat Cancer Inst. 85:704710, 1993 | ||||
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