Effect of exenatide, metformin and folic acid on experimentally induced metabolic–cognitive syndrome in rats | ||||
| Benha Medical Journal | ||||
| Article 8, Volume 37, Issue 1, May 2020, Page 229-245 PDF (1.1 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bmfj.2020.86396 | ||||
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| Authors | ||||
| Ahmed Bahriz; Mohamed Mansour; Amany Ibrahim; Doaa Khalil; Heba El-Noury | ||||
| Department of clinical pharmacology, Benha faculty of medicine, Banha University, Egypt | ||||
| Abstract | ||||
| Background: Metabolic syndrome (MetS) and its relationship with cognitive impairment has been the subject of extensive research. Purpose: This study was designed to determine the effect of MetS on cognitive function, and the possibility of modulating this effect by exenatide, metformin and folic acid. Materials and Methods: 30 adult male albino rats were divided in 5 groups. Group (I): received a standard rat chow, group (II): none treated rats with MetS fed with 60% fructose added to the standard rat chow, group (III): rats with MetS treated with exenatide, group (IV): rats with MetS treated with metformin, group (V): rats with MetS treated with folic acid. At the end of the experiment, fasting blood glucose, fasting plasma insulin, HOMA-IR index, serum triglyceride, HDL-C, dopamine and BDNF levels in brain tissue were measured and cognitive performance was assessed by Morris water maze (MWM) test. Results: rats with MetS showed increased levels of fasting blood glucose, fasting plasma insulin, HOMA-IR index, arterial blood pressure, serum triglycerides, decreased HDL-C, dopamine and BDNF and showed memory impairment in MWM test. All treated groups resulted in decrease in fasting blood glucose, fasting plasma insulin, HOMA-IR index, arterial blood pressure, and serum triglycerides and increase in HDL-C, dopamine and BDNF as well as improvement in MWM test. Conclusion: MetS was associated with cognitive impairment. Exenatide, metformin and folic acid improved cognitive function in addition to improvement of metabolic parameters. | ||||
| Keywords | ||||
| cognition; exenatide; folic acid; metabolic syndrome; metformin | ||||
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