Role of Botulinum Toxin Type A in Management of Vocal Fold Contact Granuloma Meta-Analysis Study | ||||
| The Egyptian Journal of Hospital Medicine | ||||
| Article 16, Volume 71, Issue 4, April 2018, Page 2963-2973 PDF (556.35 K) | ||||
| Document Type: Original Article | ||||
 View on SCiNiTO | ||||
| Author | ||||
| Ahmed A. Mohamed, Amr N. Rabie, Marwa M. ElBegermy, Wael A. Sobih | ||||
| Department of Otorhinolaryngology, Faculty of Medicine, Ain-Shams University | ||||
| Abstract | ||||
| Background: granulomas of the vocal process of the larynx are benign lesions of the posterior glottis generally centered over the tips of the cartilaginous vocal processes. Clinically they are associated with odynophagia, throat clearing, globus, and otalgia. Aim of the Work: this meta-analysis study aimed to know the role of botulinum toxin type A in management of vocal fold contact granuloma. Materials and Methods: this study strictly followed the recommendation of referred reporting items for systematic reviews and meta-analyses (PRISMA) statement. It was done in the following steps: target determination, identification the location of articles, screening and evaluation, data collection, data analysis and finally reporting and interpretation. Results: there was acceptable complete response rate of contact granuloma to botulinum toxin injection with event rate of 85.422% while rate of improvement among selected cases was 92.962%. Concerning to complications the most common complication was hoarsness of voice with rate of 52.737% while dysphagia was 21.125% among cases. Conclusion: botulinum toxin is a safe and effective therapy in resolving vocal process granulomas. Complete response and partial response are significant in our study also decreased Valsalva effort, failure rate and relapse rate are all significant outcomes. While temporary post injection hoarsness of voice, dysphagia, local pain at injection sites and fluid aspiration considered non significant outcomes. | ||||
| Keywords | ||||
| Botulinum toxin type A; vocal fold contact granuloma | ||||
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