p63 & ki67 antigen expression in relation to the aggressiveness of oral squamous cell carcinoma
Kamal, K., Mohamed, M., Abd-alwahab, A., Alazazi, M. (2020). p63 & ki67 antigen expression in relation to the aggressiveness of oral squamous cell carcinoma. EKB Journal Management System, 66(Issue 2 - April (Oral Medicine, X-Ray, Oral Biology & Oral Pathology)), 1091-1098. doi: 10.21608/edj.2020.23986.1009
Kamal Abd EL-Rahman Kamal; Mohamed Abdelrahman Mohamed; Amr Saad Abd-alwahab; Magdi Alazazi. "p63 & ki67 antigen expression in relation to the aggressiveness of oral squamous cell carcinoma". EKB Journal Management System, 66, Issue 2 - April (Oral Medicine, X-Ray, Oral Biology & Oral Pathology), 2020, 1091-1098. doi: 10.21608/edj.2020.23986.1009
Kamal, K., Mohamed, M., Abd-alwahab, A., Alazazi, M. (2020). 'p63 & ki67 antigen expression in relation to the aggressiveness of oral squamous cell carcinoma', EKB Journal Management System, 66(Issue 2 - April (Oral Medicine, X-Ray, Oral Biology & Oral Pathology)), pp. 1091-1098. doi: 10.21608/edj.2020.23986.1009
Kamal, K., Mohamed, M., Abd-alwahab, A., Alazazi, M. p63 & ki67 antigen expression in relation to the aggressiveness of oral squamous cell carcinoma. EKB Journal Management System, 2020; 66(Issue 2 - April (Oral Medicine, X-Ray, Oral Biology & Oral Pathology)): 1091-1098. doi: 10.21608/edj.2020.23986.1009

p63 & ki67 antigen expression in relation to the aggressiveness of oral squamous cell carcinoma

Egyptian Dental Journal
Article 16, Volume 66, Issue 2 - April (Oral Medicine, X-Ray, Oral Biology & Oral Pathology), April 2020, Page 1091-1098  XML PDF (2.4 MB)
Document Type: Original Article
DOI: 10.21608/edj.2020.23986.1009
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Authors
Kamal Abd EL-Rahman Kamal email 1; Mohamed Abdelrahman Mohamed2; Amr Saad Abd-alwahab3; Magdi Alazazi4
1Lecturer of Oral and Dental Pathology, Department of Oral and Dental Pathology, Faculty of Dental Medicine (Cairo - Boys) Al-Azhar University, Egypt
2Assistant Professor of Oral Pathology - Faculty of Dentistry - Al-Azhar University
3Lecturer of Oral Pathology - Faculty of Dentistry - Al-Azhar University
4Lecturer of Oral biology - Faculty of Dentistry - Al-Azhar University
Abstract
Abstract:
Aim: To investigate the expression of p63 protein and ki67 antigen in a series of graded OSCC to evaluate the potential association between the expression of the two markers and the aggressiveness of histologic grades of OSCC. Methods: Hematoxylin and Eosin (H&E) and streptavidin-biotin immunoperoxidase staining techniques was used to detect the expression of p63 & ki67 in different grades of OSCC. Evaluation of immunostaining was done using computer image analyzer system & statistical analysis. Results: regarding p63 & ki67 expression were obtained by comparing the area % between different grading of OSSC, there was a statistically highly significant difference between different grades of OSCC (P<0.01) & there was a statistically significant direct correlation between p63 & ki67 stain. Conclusion: These results suggest that p63 & ki67 could reflect biological features, such as proliferation and differentiation for recognition of clinical behavior of OSCC also p63 & ki67 alteration may be associated with the progression of these neoplasms.
Keywords
OSCC; immunohistochemical markers; p63; ki67
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