IMMUNOHISTOCHEMICAL VALIDATION OF INSULIN-LIKE GROWTH FACTOR II mRNA-BINDING PROTEIN 3 (IMP3) AS A DIAGNOSTIC MARKER IN SALIVARY GLAND TUMORS
Abou Madawi, N., El Sheikh, S., Riad, S., Swaify, G., Omar, E. (2020). IMMUNOHISTOCHEMICAL VALIDATION OF INSULIN-LIKE GROWTH FACTOR II mRNA-BINDING PROTEIN 3 (IMP3) AS A DIAGNOSTIC MARKER IN SALIVARY GLAND TUMORS. EKB Journal Management System, 45(2), 38-43. doi: 10.21608/adjalexu.2020.86767
Nourhan A. Abou Madawi; Sahar M. El Sheikh; Sahar E. Riad; Gamal A. Swaify; Enas M. Omar. "IMMUNOHISTOCHEMICAL VALIDATION OF INSULIN-LIKE GROWTH FACTOR II mRNA-BINDING PROTEIN 3 (IMP3) AS A DIAGNOSTIC MARKER IN SALIVARY GLAND TUMORS". EKB Journal Management System, 45, 2, 2020, 38-43. doi: 10.21608/adjalexu.2020.86767
Abou Madawi, N., El Sheikh, S., Riad, S., Swaify, G., Omar, E. (2020). 'IMMUNOHISTOCHEMICAL VALIDATION OF INSULIN-LIKE GROWTH FACTOR II mRNA-BINDING PROTEIN 3 (IMP3) AS A DIAGNOSTIC MARKER IN SALIVARY GLAND TUMORS', EKB Journal Management System, 45(2), pp. 38-43. doi: 10.21608/adjalexu.2020.86767
Abou Madawi, N., El Sheikh, S., Riad, S., Swaify, G., Omar, E. IMMUNOHISTOCHEMICAL VALIDATION OF INSULIN-LIKE GROWTH FACTOR II mRNA-BINDING PROTEIN 3 (IMP3) AS A DIAGNOSTIC MARKER IN SALIVARY GLAND TUMORS. EKB Journal Management System, 2020; 45(2): 38-43. doi: 10.21608/adjalexu.2020.86767

IMMUNOHISTOCHEMICAL VALIDATION OF INSULIN-LIKE GROWTH FACTOR II mRNA-BINDING PROTEIN 3 (IMP3) AS A DIAGNOSTIC MARKER IN SALIVARY GLAND TUMORS

Alexandria Dental Journal
Article 7, Volume 45, Issue 2, August 2020, Page 38-43  XML PDF (1.02 MB)
Document Type: Original Article
DOI: 10.21608/adjalexu.2020.86767
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Authors
Nourhan A. Abou Madawi email 1; Sahar M. El Sheikh2; Sahar E. Riad2; Gamal A. Swaify3; Enas M. Omar4
1Instructor in Oral Pathology Department, Faculty of Dentistry, Alexandria University.
2Professor in Oral Pathology Department, Faculty of Dentistry, Alexandria University.
3Professor in Cranio-Maxillofacial and Plastic Surgery Department, Faculty of Dentistry, Alexandria University.
4Lecturer in Oral Pathology Department, Faculty of Dentistry, Alexandria University.
Abstract
Introduction: Salivary gland tumors (SGTs) are infrequent tumours accounting for 2-6.5% of all head and neck tumors. They show various clinical behaviours and different histological patterns resulting in a diagnostic dilemma. Insulin like growth factor II RNA binding protein 3 (IMP3) is an oncofetal protein that plays an important role in tumor invasion and metastases. Several studies proved the prognostic role of IMP3 in different human cancers. However, its role in SGTs still needs to be confirmed.
Objectives: To evaluate IMP3 immunoexpression in benign and malignant SGTs.
Material and Methods: IMP3 expression was measured in 44 SGT cases (20 benign and 24 malignant) and 10 normal salivary gland tissues (NSGT).   Immunohistochemical (IHC) staining was carried out by the Labeled Strept-Avidin Biotin complex method (LSAB).
 Results: IMP3 expression was detected in NSGT as well as benign and malignant SGTs with different intensities.  The Lowest expression levels were detected in NSGT, while the highest ones were detected in Malignant SGTs.
Conclusion: IMP3 could be used as a diagnostic marker in SGTs.
Keywords
Salivary gland tumors; IMP3; immunohistochemical marker; prognosis
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