Synthesis, Molecular Docking and Antimicrobial Activities of 3-Formyl-2- (1H)quinolinone Schiff Base Derivatives and 3-(((3-Acetylphenyl)imino)- methyl)quinolin-2-(1H)-one Chalcone Derivatives
maigali, S., tawfik, H., Ali, M., Soliman, F., Mohramb, M., dondeti, M. (2020). Synthesis, Molecular Docking and Antimicrobial Activities of 3-Formyl-2- (1H)quinolinone Schiff Base Derivatives and 3-(((3-Acetylphenyl)imino)- methyl)quinolin-2-(1H)-one Chalcone Derivatives. EKB Journal Management System, 63(10), 3903-3914. doi: 10.21608/ejchem.2020.27574.2580
sohier maigali; hanaa awad tawfik; Mansoura Ali; Fouad Soliman; Maysa E. Mohramb; Mahmoud Fathy dondeti. "Synthesis, Molecular Docking and Antimicrobial Activities of 3-Formyl-2- (1H)quinolinone Schiff Base Derivatives and 3-(((3-Acetylphenyl)imino)- methyl)quinolin-2-(1H)-one Chalcone Derivatives". EKB Journal Management System, 63, 10, 2020, 3903-3914. doi: 10.21608/ejchem.2020.27574.2580
maigali, S., tawfik, H., Ali, M., Soliman, F., Mohramb, M., dondeti, M. (2020). 'Synthesis, Molecular Docking and Antimicrobial Activities of 3-Formyl-2- (1H)quinolinone Schiff Base Derivatives and 3-(((3-Acetylphenyl)imino)- methyl)quinolin-2-(1H)-one Chalcone Derivatives', EKB Journal Management System, 63(10), pp. 3903-3914. doi: 10.21608/ejchem.2020.27574.2580
maigali, S., tawfik, H., Ali, M., Soliman, F., Mohramb, M., dondeti, M. Synthesis, Molecular Docking and Antimicrobial Activities of 3-Formyl-2- (1H)quinolinone Schiff Base Derivatives and 3-(((3-Acetylphenyl)imino)- methyl)quinolin-2-(1H)-one Chalcone Derivatives. EKB Journal Management System, 2020; 63(10): 3903-3914. doi: 10.21608/ejchem.2020.27574.2580

Synthesis, Molecular Docking and Antimicrobial Activities of 3-Formyl-2- (1H)quinolinone Schiff Base Derivatives and 3-(((3-Acetylphenyl)imino)- methyl)quinolin-2-(1H)-one Chalcone Derivatives

Egyptian Journal of Chemistry
Article 30, Volume 63, Issue 10, October 2020, Page 3903-3914  XML PDF (518.19 K)
Document Type: Original Article
DOI: 10.21608/ejchem.2020.27574.2580
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Authors
sohier maigali1; hanaa awad tawfik2; Mansoura Ali email 3; Fouad Soliman4; Maysa E. Mohramb5; Mahmoud Fathy dondeti6
1National Research center
21Chemistry of Natural and Microbial Products Department, National Research Center, Dokki, Giza, Egypt.
3National Research Centre,Dept. of Organometallic and Organometalloid Chemisry
4Organometallic and organometalloid chemistry dept
5a Department of Organometallic and Organometalloid Chemistry, b Microbial Chemistry Department, National Research Centre,
6National Research Centre
Abstract
Some of Schiff base derivatives were separated by condensing 3-formyl-2-quinolinone with various primary amine derivatives in ethanol, in which water is expelled. Moreover, substituted acryloylphenyliminomethylquinolinone chalcone derivatives were prepared by the process of condensation reaction of aldehyde derivatives with 3-acetylphenylquinolinone in dilute solution of ethanolic sodium hydroxide via Claisen-Schmidt condensation method. Cyclization reaction of the quinolinone chalcones with malononitrile, phenylhydrazine, urea and thiourea were also investigated. The structures of these compounds have been elucidated on the bases of spectral data. The novel products were also evaluated for their antimicrobial activity.
Keywords
2-Oxo-3-formaldehyde quinoline; primary amines; aldehydes; Claisen-Schmidt condensation; molecular docking; antimicrobial evaluation
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