Management Approaches to Hairy Cell Leukemia; Overview | ||||
| The Egyptian Journal of Hospital Medicine | ||||
| Article 9, Volume 71, Issue 1, April 2018, Page 2257-2261 PDF (267.96 K) | ||||
| Document Type: Original Article | ||||
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| Author | ||||
| Akeelah Abdullah Al-Haddad, Batool Saad Alsalim, Huriyyah Alawi AlJarrash, Halah Ahmad Alfaraj, Ranim Yahya Nasr | ||||
| King Salman Hospital, Riyadh, Saudi Arabia | ||||
| Abstract | ||||
| Hairy cell leukemia is a rare disease comprising about 2% of lymphoid neoplasms. In this review, the biology, diagnostic criteria, and current therapeutic options in HCL-V and HCL-JV are presented.We conducted a database; PubMed and Embase comprehensive search up to December 2017, we search a relevant trail to our concern topic (hairy cell leukemia). HCL-V is a distinct clinico-pathological entity. However, differentiating HCL-V from classical HCL and splenic marginal zone lymphoma (SMZL), which are both connected with noticeable splenomegaly and circulating neoplastic cells with 'hairy' projections remain a problem. Patients with HCL-V are usually older, splenomegaly is less typical and leucopenia with granulocytopenia and monocytopenia are generally not seen. Bone marrow is usually easily aspirable, hyper-cellular with mild myelofibrosis. | ||||
| Keywords | ||||
| Hairy cell leukemia; Treatment; Irradiation; Leukemia; Management | ||||
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