Recognition and adsorption characteristics of tramadol hydrochloride molecules in molecular imprinted poly(MAA-co-EGDMA)
Morsi, S., N.A., A., Abd-elFatah, N., Morsi, M., Shaker, N. (2020). Recognition and adsorption characteristics of tramadol hydrochloride molecules in molecular imprinted poly(MAA-co-EGDMA). EKB Journal Management System, 63(11), 4565-4578. doi: 10.21608/ejchem.2020.26005.2517
Samir M.M. Morsi; Alian N.A.; Naglaa N. Abd-elFatah; Morsi M. Morsi; Nihal Shaker. "Recognition and adsorption characteristics of tramadol hydrochloride molecules in molecular imprinted poly(MAA-co-EGDMA)". EKB Journal Management System, 63, 11, 2020, 4565-4578. doi: 10.21608/ejchem.2020.26005.2517
Morsi, S., N.A., A., Abd-elFatah, N., Morsi, M., Shaker, N. (2020). 'Recognition and adsorption characteristics of tramadol hydrochloride molecules in molecular imprinted poly(MAA-co-EGDMA)', EKB Journal Management System, 63(11), pp. 4565-4578. doi: 10.21608/ejchem.2020.26005.2517
Morsi, S., N.A., A., Abd-elFatah, N., Morsi, M., Shaker, N. Recognition and adsorption characteristics of tramadol hydrochloride molecules in molecular imprinted poly(MAA-co-EGDMA). EKB Journal Management System, 2020; 63(11): 4565-4578. doi: 10.21608/ejchem.2020.26005.2517

Recognition and adsorption characteristics of tramadol hydrochloride molecules in molecular imprinted poly(MAA-co-EGDMA)

Egyptian Journal of Chemistry
Article 35, Volume 63, Issue 11, November 2020, Page 4565-4578  XML PDF (1.21 MB)
Document Type: Original Article
DOI: 10.21608/ejchem.2020.26005.2517
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Authors
Samir M.M. Morsi email 1; Alian N.A.2; Naglaa N. Abd-elFatah3; Morsi M. Morsi4; Nihal Shaker5
1polymers and pigments dept. national research centre
2Department of Chemistry, Faculty of Science, Al-Azhar University, Cairo, Egypt,
3Analytical Toxicology Laboratory, Forensic Medicine Authority, Ministry of Justice, Cairo, Egypt.
4Glass Research Department, National Research Center, 33 El Bohoth St.,Dokki, Giza, Egypt.
5Faculty of Science, Al-Azhair University
Abstract
A simple method for adsorption and recognition of tramadol-HCl in molecular imprinted poly (methacrylic acid-co-ethylene glycol dimethacrylate); poly (MAA-co-EGDMA), is described. Seven tramadol imprinted polymers (TIPs) were synthesized based on tramadol hydrochloride as the template molecule, methacrylic acid (MAA) as a functional monomer, ethylene glycol dimethacrylate (EGDMA) as a crosslinker, chloroform as a porogenic solvent and benzoyl peroxide (BP) as an initiator. Other seven non-imprinted polymers (NIPs) were prepared with the same compositions as the TIPs without the template molecule. A simple method for determination of Tramadol concentration by optical absorption method was described. The effects of crosslinker and functional monomer concentration, soaking time and the pH on the adsorption efficiency of tramadol by the polymers were studied. TIPs exhibited more adsorption affinity than their NIPs counterparts as they acquired recognition sites to capture the tramadol molecules. The TIP polymer with 15 mmol EGDMA and 1.15 mmol MAA stirred for 3h at 7 pH tramadol solution showed 90% adsorption capability for the tramadol, while the corresponding NIP sample showed 55.6% adsorption. SEM images showed the presence of (micro/meso/macro) pores in such TIP sample.
Keywords
Tramadol determination; imprinted polymer; tramadol adsorption; optical absorption; crosslinker
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